Modulation of gamma-aminobutyric acid (GABA) receptors and the feeding response by neurosteroids in Hydra vulgaris

Neuroscience
A ConcasG Biggio

Abstract

Gamma-Aminobutyric acid (GABA) receptors are present in membrane preparations from Hydra vulgaris, one of the most primitive organisms with a nervous system. These receptors are sensitive to muscimol and benzodiazepines and appear to be important in the regulation of the feeding response. The effects of neurosteroids, general anaesthetics, and GABA antagonists on GABA(A) receptors in membranes prepared from Hydra and on the feeding response have now been investigated. The neurosteroids tetrahydroprogesterone and tetrahydrodeoxycorticosterone increased [3H]GABA binding to hydra membranes with nanomolar potency (EC50, 141+/-11 and 623+/-36 nM, respectively) and high efficacy (maximal increase 79+/-6.5 and 62+/-4%, respectively), whereas the 3beta-hydroxy epimer of tetrahydroprogesterone was ineffective. The benzodiazepine receptor ligands diazepam (100 microM), clonazepam (100 microM) and abecarnil (30 microM) enhanced [3H]GABA binding to Hydra membranes by 22, 20 and 24%, respectively; effects abolished by the specific benzodiazepine antagonist flumazenil (100 microM). On the contrary, the peripheral benzodiazepine receptor ligand 4'chlorodiazepam failed to affect [3H]GABA binding to Hydra membranes. The general anaesthetics pro...Continue Reading

References

Apr 1, 1978·European Journal of Pharmacology·C Braestrup, R F Squires
Sep 15, 1992·Biochimica Et Biophysica Acta·W GrosvenorD E Rhoads
Jan 1, 1992·Neurology·J J Halperin, M P Heyes
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·D BelelliK W Gee
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G D Guthrie, C S Nicholson-Guthrie
Aug 1, 1988·British Journal of Pharmacology·J A PetersA J Turner
Nov 29, 1986·Brain Research·J N CrawleyS M Paul
Mar 1, 1987·British Journal of Pharmacology·G A CottrellJ A Peters
Dec 10, 1984·Brain Research·N L Harrison, M A Simmonds
May 6, 1983·European Journal of Pharmacology·J H Skerritt, G A Johnston
Dec 1, 1983·Journal of Neurochemistry·R W Olsen, A M Snowman
Mar 23, 1984·European Journal of Pharmacology·R W OlsenJ K Wamsley
Sep 1, 1995·Trends in Pharmacological Sciences·J J LambertJ A Peters
Jan 1, 1994·Annual Review of Neuroscience·R L Macdonald, R W Olsen
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·R ChenN C Lan
Jun 1, 1996·Chemical Senses·W GrosvenorG Kass-Simon
Dec 1, 1996·Journal of Neurocytology·I A Westfall
Jan 1, 1986·Neurochemistry International·S C Lummis, D B Sattelle

❮ Previous
Next ❯

Citations

Oct 25, 2008·Psychopharmacology·Helena HedströmTorbjörn Bäckström
Dec 18, 2001·Brain Research. Brain Research Reviews·S H MellonN A Compagnone
Jun 18, 2002·Neuroscience Research·Koichiro TakashimaKazuhiko Sasaki
Oct 31, 2001·Neuroscience Letters·M J Snyder, H V Peeke
Sep 27, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·G Kass-SimonP Pierobon
Feb 28, 2002·The European Journal of Neuroscience·P PierobonA Concas
Nov 15, 2013·Proceedings. Biological Sciences·Sue-Ann WatsonPhilip L Munday
Sep 26, 2013·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Larry J MinterLysa P Posner
Nov 26, 2013·Molecular Biology and Evolution·Anna-Maria HartmannOlaf R P Bininda-Emonds
Jul 31, 2007·Microscopy Research and Technique·Paola RamoinoRenata Manconi
Jul 28, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·R D RuggieriG Kass-Simon
Nov 19, 2004·The European Journal of Neuroscience·Paola PierobonAlessandra Concas
Jan 31, 2015·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Jenessa GjeltemaMichael Stoskopf
Oct 6, 2016·Royal Society Open Science·Corie L Charpentier, Jonathan H Cohen
Oct 12, 2007·Physiological Reviews·Yehezkel Ben-AriRustem Khazipov
Feb 21, 2019·Scientific Reports·Mareen MoellerPeter J Schupp
May 20, 2015·The Journal of Experimental Biology·Paola Pierobon
Nov 15, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·G Kass-Simon, Paola Pierobon
Oct 12, 2021·Pflügers Archiv : European journal of physiology·Sergii Snigirov, Sergiy Sylantyev

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.