Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domains

The FEBS Journal
Pei-Yao LiuShih-Ming Huang

Abstract

Glucocorticoid receptor-interacting protein 1 (GRIP1), a p160 family nuclear receptor co-activator, possesses at least two autonomous activation domains (AD1 and AD2) in the C-terminal region. AD1 activity appears to be mediated by CBP/p300, whereas AD2 activity is apparently mediated through co-activator-associated arginine methyltransferase 1 (CARM1). The mechanisms responsible for regulating the activities of AD1 and AD2 are not well understood. We provide evidence that the GRIP1 C-terminal region may be involved in regulating its own transactivation and nuclear receptor co-activation activities through primary self-association and a repression domain. We also compared the effects of the GRIP1 C terminus with those of other factors that functionally interact with the GRIP1 C terminus, such as CARM1. Based on our results, we propose a regulatory mechanism involving conformational changes to GRIP1 mediated through its intramolecular and intermolecular interactions, and through modulation of the effects of co-repressors on its repression domains. These are the first results to indicate that the structural components of GRIP1, especially those of the C terminus, might functionally modulate its putative transactivation activities...Continue Reading

References

Jan 1, 1989·Journal of Steroid Biochemistry·A O BrinkmannE Mulder
Jan 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·G E FolkersP T Van der Saag
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·H HongM R Stallcup
Sep 5, 1996·Nature·D ChakravartiR M Evans
Dec 19, 1996·Nature·A J Bannister, T Kouzarides
Apr 1, 1997·Current Opinion in Cell Biology·C K GlassM G Rosenfeld
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·H LiJ D Chen
Sep 20, 1997·Nature·T E SpencerB W O'Malley
Jun 17, 1998·Genes & Development·J C BlancoK Ozato
May 14, 1999·Current Opinion in Genetics & Development·L XuM G Rosenfeld
Jun 26, 1999·Science·D ChenM R Stallcup
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·N J McKennaB W O'Malley
Sep 16, 1999·The EMBO Journal·E A MiskaT Kouzarides
Nov 24, 1999·Molecular and Cellular Biology·C L BevanM G Parker
Feb 12, 2000·Molecular and Cellular Biology·S M Huang, M R Stallcup
Sep 30, 2000·The Journal of Biological Chemistry·D ChenM R Stallcup
Oct 11, 2002·The EMBO Journal·Martine Chevillard-BrietLaurence Vandel
Nov 12, 2002·The EMBO Journal·Akihiro ItoTso-Pang Yao
Jul 1, 2005·Molecular and Cellular Biology·Yong-Heng ChenMichael R Stallcup

❮ Previous
Next ❯

Citations

Aug 25, 2009·Nature Reviews. Cancer·Jianming XuBert W O'Malley
Aug 11, 2007·Molecular and Cellular Endocrinology·Olivier Kassel, Peter Herrlich
Mar 23, 2007·Biochemical and Biophysical Research Communications·Meng-Hsun WuShih-Ming Huang
Mar 6, 2007·The International Journal of Biochemistry & Cell Biology·Yung-Lung ChangShih-Ming Huang
Jul 8, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Maria M SzwarcBert W O'Malley
Aug 21, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Maria M SzwarcBert W O'Malley
Jun 4, 2019·Endocrinology·Malachi A Blundon, Subhamoy Dasgupta
Mar 21, 2007·Cellular Signalling·Shaosi Li, Yongfeng Shang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.