Modulation of Glucose Takeup by Glucose Transport on the Isolated OHCs

Neural Plasticity
Xiao-Ting ChengNing Yu

Abstract

Glucose is a fundamental source of energy for mammalian cells; however, whether glucose is taken up through the lateral walls of cochlear outer hair cells (OHCs) is unknown. The OHC lateral wall is complex, composed of a plasma membrane, cortical lattice, and subsurface cisternae. This study assessed the uptake of glucose by OHCs using live-cell microscopy and examined the distribution of glucose transporter isoforms by immunohistochemistry. We found that glucose transporter-4 was mostly expressed on the lateral wall of OHCs. Glucose crossed the lateral walls of OHCs via glucose transporters-4 mainly, and this process could be modulated. These results suggest that the lateral walls are involved in modulating energy transport into OHCs.

References

Feb 12, 2002·Nature Reviews. Molecular Cell Biology·Peter Dallos, Bernd Fakler
Aug 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maria KukleyDirk Dietrich
Dec 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hong-Bo ZhaoCarrie R Fleming
May 20, 2006·Brain Research·Ning YuHong-Bo Zhao
Apr 20, 2007·Developmental Neurobiology·Xudong WuJian Zuo
Jan 16, 2008·Physiological Reviews·Jonathan Ashmore
May 21, 2008·Pflügers Archiv : European journal of physiology·Ning Yu, Hong-Bo Zhao
Oct 14, 2008·Biochemical Pharmacology·Samantha F Moore, Amanda B Mackenzie
Aug 5, 2011·Science Translational Medicine·Denise A ChanAmato J Giaccia
Feb 14, 2012·Biophysical Journal·Sripriya Ramamoorthy, Alfred L Nuttall
Apr 16, 2013·Cell and Tissue Research·Eva DegermanMåns Magnusson
May 9, 2013·Nature Communications·Yan ZhuHong-Bo Zhao
Jun 13, 2013·Journal of Cellular Physiology·Carlos WilsonManuel Estrada
Feb 5, 2015·Biophysical Journal·Lei Song, Joseph Santos-Sacchi

❮ Previous
Next ❯

Methods Mentioned

BETA
Antibody

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
Y LiP Wang
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
David Z Z HePeter Dallos
© 2022 Meta ULC. All rights reserved