Modulation of gut microbiota through nutritional interventions in Behçet's syndrome patients (the MAMBA study): study protocol for a randomized controlled trial.

Trials
Giuditta PAGLIAIFrancesco SOFI

Abstract

Behçet's syndrome (BS) is a systemic inflammatory disorder of unknown etiology, and it is characterized by a wide range of potential clinical manifestations. Recent evidence suggests that the gut microbiota (GM) in BS has low biodiversity with a significant depletion in butyrate producers. The aim of the present project is to investigate whether a dietary intervention could ameliorate the clinical manifestations and modulate the GM of individuals with BS. This is a randomized, open, cross-over study that involves 90 individuals with BS, who will be randomly assigned to one of three different diets for 3 months: a lacto-ovo-vegetarian diet (VD), a Mediterranean diet (MD), or a Mediterranean diet supplemented with butyrate (MD-Bt). The VD will contain inulin-resistant and resistant-starch-rich foods, eggs, and dairy in addition to plant-based food, but it will not contain meat, poultry, or fish. The MD will contain all food categories and will provide two portions per week of fish and three portions per week of fresh and processed meat. The MD-Bt will be similar to the MD but supplemented with 1.8 g/day of oral butyrate. The three different diets will be isocaloric and related to the participants' nutritional requirements. Anthro...Continue Reading

Associated Clinical Trials

References

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Citations

Nov 14, 2020·Current Opinion in Rheumatology·Shahna Tariq, Alison H Clifford
Jun 3, 2021·Clinical Reviews in Allergy & Immunology·Jingjing Chen, Xu Yao
Jun 8, 2021·Frontiers in Medicine·Gonca Mumcu, Farida Fortune
Jun 8, 2021·Frontiers in Immunology·Nafeesa MehmoodGraham R Wallace

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

made4
stats
vegan
DASH
IN
SPSS
PANDAseq
R
Adonis
Diva

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