Modulation of hepatic inflammation and energy-sensing pathways in the rat liver by high-fructose diet and chronic stress

European Journal of Nutrition
Nataša VeličkovićGordana Matić

Abstract

High-fructose consumption and chronic stress are both associated with metabolic inflammation and insulin resistance. Recently, disturbed activity of energy sensor AMP-activated protein kinase (AMPK) was recognized as mediator between nutrient-induced stress and inflammation. Thus, we analyzed the effects of high-fructose diet, alone or in combination with chronic stress, on glucose homeostasis, inflammation and expression of energy sensing proteins in the rat liver. In male Wistar rats exposed to 9-week 20% fructose diet and/or 4-week chronic unpredictable stress we measured plasma and hepatic corticosterone level, indicators of glucose homeostasis and lipid metabolism, hepatic inflammation (pro- and anti-inflammatory cytokine levels, Toll-like receptor 4, NLRP3, activation of NFκB, JNK and ERK pathways) and levels of energy-sensing proteins AMPK, SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α). High-fructose diet led to glucose intolerance, activation of NFκB and JNK pathways and increased intrahepatic IL-1β, TNFα and inhibitory phosphorylation of insulin receptor substrate 1 on Ser307. It also decreased phospho-AMPK/AMPK ratio and increased SIRT1 expression. Stress alone increased plasm...Continue Reading

References

May 23, 1998·Annual Review of Immunology·S GhoshE B Kopp
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Nov 6, 2002·The Journal of Biological Chemistry·Yong Hee LeeMorris F White
Dec 31, 2003·Trends in Immunology·Paresh DandonaArindam Bandyopadhyay
Jul 16, 2005·Stress : the International Journal on the Biology of Stress·Marian JoëlsHarm J Krugers
Nov 1, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·Isabelle A LeclercqYves J Horsmans
Feb 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Núria RoglansJuan Carlos Laguna
Jan 15, 2008·Journal of Neuroimmunology·Yi ZhangDeling Yin
Sep 25, 2009·The Journal of Nutrition·Takahiro KawasakiToshikazu Yamanouchi
Oct 6, 2009·Biochemical and Biophysical Research Communications·Hyun-Young KooManabu T Nakamura
Feb 18, 2010·Molecular and Cellular Biology·Xiao-Dong YangLin-Feng Chen
Apr 2, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lene N AxelsenAnne Louise Kjølbye
Apr 8, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Giovanni Solinas, Michael Karin
Apr 23, 2010·Psychosomatic Medicine·Janice K Kiecolt-Glaser
Jul 30, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qingqing LiuHarvey Lodish
Sep 9, 2010·American Journal of Physiology. Endocrinology and Metabolism·Mark J DekkerKhosrow Adeli
Jan 8, 2011·The Journal of Endocrinology·Paul W CatonRoger Corder
Mar 25, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Antero SalminenKai Kaarniranta
Sep 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna DittrichFred Schaper
Oct 25, 2011·The British Journal of Nutrition·Sabine WagnerbergerIna Bergheim
Jan 10, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hongming MiaoLixia Gan
Jun 19, 2012·The Biochemical Journal·David CarlingMatthew J Sanders
Dec 21, 2012·The Journal of Nutritional Biochemistry·Biljana N BursaćGordana M Matić
Mar 23, 2013·Molecular Endocrinology·Josefa AndradeMargaret A Shupnik
Jun 5, 2013·Molecular and Cellular Endocrinology·Ping JiaoHaiyan Xu
Jun 19, 2013·The Journal of Nutritional Biochemistry·Ana VasiljevićGordana Matić
Jul 19, 2013·The Journal of Clinical Investigation·Neil B RudermanJosé M Cacicedo
Jul 9, 2014·Psychoneuroendocrinology·Amy E B PackardYvonne M Ulrich-Lai
Feb 24, 2015·Frontiers in Psychiatry·Susana MonteiroJoão José Cerqueira
Feb 26, 2015·Physiology & Behavior·Abigail K ThompsonYvonne M Ulrich-Lai
Feb 27, 2015·Hormone Molecular Biology and Clinical Investigation·Cidália D PereiraMaria João Martins
Jun 27, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Torfay SharifniaCharles R Flynn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here