Modulation of hippocampal theta and hippocampal-prefrontal cortex function by a schizophrenia risk gene.

Human Brain Mapping
Helena CousijnPaul J Harrison

Abstract

Hippocampal theta-band oscillations are thought to facilitate the co-ordination of brain activity across distributed networks, including between the hippocampus and prefrontal cortex (PFC). Impairments in hippocampus-PFC functional connectivity are implicated in schizophrenia and are associated with a polymorphism within the ZNF804A gene that shows a genome-wide significant association with schizophrenia. However, the mechanisms by which ZNF804A affects hippocampus-PFC connectivity are unknown. We used a multimodal imaging approach to investigate the impact of the ZNF804A polymorphism on hippocampal theta and hippocampal network coactivity. Healthy volunteers homozygous for the ZNF804A rs1344706 (A[risk]/C[nonrisk]) polymorphism were imaged at rest using both magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI). A dual-regression approach was used to investigate coactivations between the hippocampal network and other brain regions for both modalities, focusing on the theta band in the case of MEG. We found a significant decrease in intrahippocampal theta (using MEG) and greater coactivation of the superior frontal gyrus with the hippocampal network (using fMRI) in risk versus nonrisk homozygotes. Furthe...Continue Reading

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Citations

Feb 10, 2016·Frontiers in Systems Neuroscience·Torfi Sigurdsson, Sevil Duvarci
Aug 1, 2016·Neuroscience and Biobehavioral Reviews·Elliot Murphy, Antonio Benítez-Burraco
Sep 8, 2016·Frontiers in Human Neuroscience·Elliot Murphy, Antonio Benítez-Burraco
Dec 10, 2016·Scientific Reports·Francesca FerriMarcello Costantini
Jan 12, 2017·Trends in psychiatry and psychotherapy·Ateeq Mubarik, Hassaan Tohid
Nov 1, 2018·Human Brain Mapping·Emily RuzichJustin F Schneiderman
Apr 9, 2020·Brain Connectivity·Hamid Soltani ZangbarParviz Shahabi
Nov 16, 2019·Current Neuropharmacology·Katarzyna ChameraAgnieszka Basta-Kaim
Mar 25, 2017·Frontiers in Behavioral Neuroscience·Alexander N KalweitDenise Manahan-Vaughan
Nov 9, 2018·Frontiers in Psychology·Elliot Murphy, Antonio Benítez-Burraco
Nov 10, 2018·Current Pharmacology Reports·Yijing ZhouYingwei Mao
Apr 3, 2020·Brain : a Journal of Neurology·Rick A AdamsNeil Burgess
Dec 13, 2016·Journal of Psychiatric Research·Luis Rafael Leite SampaioSilvânia Maria Mendes de Vasconcelos
Aug 5, 2019·NeuroImage. Clinical·Kristin K LottmanAdrienne C Lahti
Sep 4, 2021·Scientific Reports·George C O'NeillGareth R Barnes

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Methods Mentioned

BETA
Genotyping
Assay

Software Mentioned

FMRIB
FMRIB Xnoiseifier
FastICA
SPM8
FieldTrip
FSL Randomise
FastTrak
Matlab
Elekta
SPSS Statistics

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