PMID: 7540644Jun 1, 1995Paper

Modulation of human G-CSF receptor mRNA and protein in normal and leukemic myeloid cells by G-CSF and retinoic acid

Journal of Leukocyte Biology
L S TkatchD J Tweardy

Abstract

Granulocyte colony-stimulating factor (G-CSF) is produced by several cell types throughout the body and has a variety of effects on neutrophils and their precursors, which are mediated by binding to its receptor. It is not yet known what physiologic factors modulate G-CSF receptor mRNA expression in these cells. We studied the effect of G-CSF on freshly isolated neutrophils and bone marrow cells from normal human subjects and on myeloid leukemic cell lines. We found that G-CSF receptor mRNA levels were maintained by G-CSF in neutrophils but not in bone marrow cells. Of the leukemic cell lines tested, K562 and BV173, both of which contain the bcr-abl translocation, neither expressed G-CSF receptor mRNA. Whereas G-CSF did not affect mRNA levels for its receptor in myeloid leukemic cell lines, exposure of the acute promyelocytic cell line, NB4, to all-trans retinoic acid induced a striking increase in G-CSF receptor mRNA expression and resulted in increased G-CSF receptor surface expression. The effect of retinoic acid on G-CSF receptor mRNA on NB4 cells occurred early, before morphologic evidence of differentiation, and required protein synthesis. All-trans retinoic acid also upregulated G-CSF receptor mRNA in the myeloid leukemi...Continue Reading

Citations

Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·P G LutzY E Cayre
Jul 13, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L H CamachoR P Warrell
Oct 3, 2002·Leukemia·P G LutzY E Cayre
Oct 22, 2002·American Journal of Physiology. Cell Physiology·Arup ChakrabortyC Wayne Smith
Oct 7, 2006·American Journal of Respiratory and Critical Care Medicine·Chiharu TabataHajime Kubo
Oct 13, 2006·American Journal of Physiology. Renal Physiology·Arup ChakrabortyDavid Sheikh-Hamad
Aug 1, 2012·Theoretical Biology & Medical Modelling·Markus ScholzMarkus Loeffler
Dec 26, 2001·Nature Genetics·Danilo PerrottiBruno Calabretta
Nov 1, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Chiharu TabataMichiaki Mishima
Dec 17, 2020·Cells·Łukasz SzymańskiArthur Zelent
Oct 24, 2000·Blood Cells, Molecules & Diseases·A ChakrabortyD J Tweardy
Mar 1, 2000·Biochemical and Biophysical Research Communications·M MisagoS Eto

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