PMID: 8964897Apr 1, 1996Paper

Modulation of humoral immune response by central administration of leucine-enkephalin: effects of mu, delta and kappa opioid receptor antagonists

Journal of Neuroimmunology
J RadulovićG Pesić

Abstract

The effect of leucine-enkephalin (Leu-Enk) on primary humoral immune response was investigated following intracerebroventricular (i.c.v.) administration of the peptide in the rat. Leu-Enk stimulated plaque-forming cell (PFC) response in rats i.c.v. injected with 0.1 and 1 micrograms/kg, whereas does of 20 and 50 micrograms/kg exerted immunosuppressive effects. I.c.v. treatment of rats with delta opioid receptor antagonist ICI 174,864 and kappa opioid receptor antagonist nor-binaltorphimine (nor-BNI) blocked stimulation and suppression of PFC response induced by Leu-Enk, respectively. The mu opioid receptor antagonist beta-funaltrexamine (beta-FNA) reversed both immunomodulatory effects produced by Leu-Enk. Since beta-FNA alone had no effect on PFC response (unlike ICI 174,864 and nor-BNI), these data showed that central effects of Leu-Enk on PFC response were mediated by brain mu opioid receptors, and suggested a possible involvement of delta and kappa opioid receptors.

References

Nov 1, 1992·The International Journal of Neuroscience·B D Janković, J Radulović
Apr 24, 1992·Brain Research·C M HsuehV K Ghanta
Apr 15, 1992·Annals of the New York Academy of Sciences·J VeljićB D Janković
Nov 1, 1991·Proceedings of the Society for Experimental Biology and Medicine·D J Carr
May 1, 1990·The Journal of Experimental Medicine·W HeagyR Finberg
Jun 1, 1989·Brain, Behavior, and Immunity·S ZalcmanH Anisman
Jan 1, 1988·Annual Review of Immunology·N E Sibinga, A Goldstein
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y ShavitJ C Liebeskind
Jan 1, 1988·International Journal of Immunopharmacology·G RoscettiL G Roda
Sep 1, 1984·British Journal of Pharmacology·A D CorbettL E Robson
Jan 1, 1984·Journal of Receptor Research·S J PatersonL E Robson
Apr 1, 1984·Clinical Immunology and Immunopathology·G C MillerN P Plotnikoff
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jean M BidlackChristopher M Tipton

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Citations

Dec 19, 2000·Biochemical and Biophysical Research Communications·S SuzukiR Y Chuang
Sep 10, 2002·Peptides·Stanislava StanojevićMirjana Dimitrijević
Jan 1, 1997·Peptides·G A OlsonA J Kastin
Apr 29, 1998·Immunological Reviews·S W KrauseR Andreesen
Dec 20, 2008·Journal of Biomedical Materials Research. Part a·W O FaridG K Hulse
Jun 20, 2020·Anais Da Academia Brasileira De Ciências·Carlos E BarriosDavid R HernÁndez

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