Modulation of IFN-gamma-induced immunogenicity by phosphatidylethanolamine-linked hyaluronic acid

Transplantation
B A YardStefan Post

Abstract

The present study was conducted to examine the possibility of modulating interferon (IFN-gamma)-induced immunogenicity by a novel compound that is composed of a PLA2 inhibitor linked to hyaluronic acid (HYPE). HYPE was tested for its effect on IFN-gamma-induced expression of MHC class I, class II, and intercellular adhesion molecule (ICAM-1) in cultured endothelial and renal proximal tubular cells by flow cytometric analysis (FACS) as well as its ability to influence T cell activation in mixed lymphocyte reaction (MLR) or after mitogen stimulation. In FACS, a profound inhibition in MHC class I and ICAM-1 staining was observed in stimulated or unstimulated cells that were incubated with HYPE. This was not due to down-regulation of antigen expression and only occurred when monoclonal antibodies, but not when polyclonal antibodies, were used. HYPE inhibited the induction of MHC class II in both cell types after IFN-gamma stimulation in a dose-dependent manner. Moreover, the induction of class II transactivator (CIITA) was completely inhibited under these conditions, most likely because it blocked the binding of IFN-gamma to the cell membrane. Addition of HYPE to MLR inhibited the proliferation of T cells and the secretion of inter...Continue Reading

References

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Citations

Jul 9, 2003·Critical Care Medicine·Grietje Ch BeckSaul Yedgar
Oct 27, 2010·Neurochemistry International·D Aguado-LleraE Arilla-Ferreiro
Sep 19, 2006·Biochimica Et Biophysica Acta·Saul YedgarDavid Shoseyov
May 2, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·M KrimskyM Ligumsky
Apr 30, 2003·World Journal of Gastroenterology : WJG·Rong GuoHua-Zhong Lu

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