Modulation of IL-1β reprogrammes the tumor microenvironment to interrupt oral carcinogenesis

Scientific Reports
Tong WuBin Cheng

Abstract

Head and neck squamous cell carcinoma (HNSCC) development is a multistage process includes the normal, dysplasia and squamous cell carcinoma (SCC) stages. Recently, increasing evidence has suggested that the tumor microenvironment (TME) is an integral part of malignant transformation. Exploring certain key node genes in TME for future intervention in dysplasia to interrupt oral carcinogenesis was the primary goal of this research. To achieve this goal, systems biology approaches were first applied to the epithelia and fibroblasts collected at sequential stages in a 4-nitroquinoline-1-oxide (4NQO) -induced rat oral carcinogenesis model. Through bioinformatics network construction, IL-1β was identified as one of the key node genes in TME during carcinogenesis. Immunohistochemical staining of human and rat samples demonstrated that IL-1β expression patterns were parallel to the stages of malignant transformation. Silencing IL-1β with lentivirus-delivered shRNA significantly inhibited oral squamous cell carcinoma cell growth both in vivo and in vitro. Based on these findings, we hypothesized that IL-1β may be a chemoprevention target in TME during oral carcinogenesis. Therefore, we targeted IL-1 in the TME by oral mucosal injection...Continue Reading

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Citations

Sep 23, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Xijuan ChenTong Wu
Sep 9, 2017·Clinical Hemorheology and Microcirculation·P Niclas BroerDeepak Narayan
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Jun 2, 2018·Journal of Immunology Research·Marconi Rego BarrosAntonio Carlos de Freitas
Nov 19, 2018·Molecular Cancer·Maryam MoossaviAmirhossein Sahebkar
Jul 9, 2020·Cancers·Cédric Rébé, François Ghiringhelli
May 16, 2018·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Tomasz KolendaKatarzyna M Lamperska
May 1, 2021·International Journal of Molecular Sciences·Sabah NisarMuzafar A Macha
May 11, 2021·Frontiers in Oncology·Natarajan BhaskaranPushpa Pandiyan
Aug 29, 2021·European Journal of Pharmacology·Abdullah Al MamunJian Xiao

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Datasets Mentioned

BETA
GSE42780

Methods Mentioned

BETA
xenograft
transfection
biopsies
electrophoresis
Chip

Software Mentioned

GeneSpring GX
GeneSpringGX
SPSS
STRING
Cytoscape

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