Modulation of IL-4-induced human IgE production in vitro by IFN-gamma and IL-5: the role of soluble CD23 (s-CD23)

Journal of Cellular Biochemistry
J PèneJ E de Vries

Abstract

IL-4 specifically induced IgE production by peripheral blood lymphocytes or by tonsil or spleen cells from healthy donors. IL-4-induced IgE synthesis was dependent on CD4+ T cells and monocytes and was blocked by IFN-gamma, IFN-alpha, and prostaglandin E-2 (PGE-2). These substances also inhibited IL-4-induced CD23 expression and subsequent release of soluble CD23 (s-CD23). In addition, IgE production was blocked by F(ab')2 fragments of an mAb against CD23. In contrast, IL-5 enhanced IL-4-induced IgE production, provided IL-4 was added at nonsaturating concentrations. This increase in IgE production correlated quantitatively with an enhanced release of s-CD23. Collectively, these results indicate that there is a correlation between s-CD23 release and IgE production. However, s-CD23 fractionated from supernatants of the lymphoblastoid cell line RPMI-8866 was ineffective in inducing IgE production in the absence of IL-4, but acted synergistically with suboptimal concentrations of IL-4. In addition, it is demonstrated that alloreactive T-cell clones produced varying concentrations of IL-4, IL-2, or IFN-gamma upon stimulation. Only supernatants of 2/4 of these T-cell clones induced a low degree of IgE synthesis, but in the presence ...Continue Reading

References

Feb 1, 1988·The Journal of Allergy and Clinical Immunology·K OhtaC H Kirkpatrick
Jun 1, 1987·The Journal of Experimental Medicine·T DefranceK Arai
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J PèneJ Banchereau
Jan 1, 1988·The Journal of Experimental Medicine·C M SnapperW E Paul
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·F D FinkelmanW E Paul
Jan 1, 1984·Annual Review of Immunology·K Ishizaka

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Citations

Apr 3, 2002·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·R J MayerA Faller
Oct 1, 1994·Molecular Immunology·S E DierksD H Conrad
Jan 1, 1991·Progress in Growth Factor Research·D W MaherG Morstyn
May 1, 1992·Research in Immunology·W C Bartlett, D H Conrad
Jul 1, 1990·The British Journal of Dermatology·B C Melnik, G Plewig
May 1, 1996·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·A L MillerM Halonen
Jul 25, 1998·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·D E CampbellA S Kemp
Feb 1, 1992·Immunological Reviews·G DelespesseM Letellier
Mar 1, 1991·The Journal of Clinical Investigation·C Y WuG Delespesse
Jun 27, 2008·Blood·Danielle T AveryStuart G Tangye
Jan 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H GascanJ E de Vries
Jul 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M CorominasE Buendia
Jun 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M P BorresB Björkstén
Sep 12, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T-N WangY-C Ko
Apr 16, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M P LaanH F Savelkoul
Feb 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·B C MelnikT Tschung
Feb 25, 1999·The Annals of Otology, Rhinology, and Laryngology·A TanakaY Nakai
Feb 17, 1998·European Journal of Immunology·G ChristieR J Mayer
Aug 1, 1992·European Journal of Immunology·K A CampbellD H Conrad
Dec 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qyana K GriffithLisa M Ganley-Leal
May 1, 1995·The Journal of Dermatology·N MaekawaY Asada
Jan 1, 1992·Immunologic Research·M SarfatiG Delespesse
Jan 1, 1994·Clinical and Experimental Immunology·M Tang, A Kemp
Aug 1, 1991·Clinical and Experimental Immunology·K A ByronA M Wootton
Apr 1, 1993·Clinical and Experimental Immunology·M TangG Varigos
Apr 11, 2001·The Journal of Allergy and Clinical Immunology·C BachertP van Cauwenberge
Dec 1, 1991·Current Opinion in Immunology·D H ConradS E Dierks

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