Modulation of immune mediators with MQT-based immunotherapy

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
John H Krouse, Helene J Krouse

Abstract

Assess immune and clinical changes with immunotherapy based on modified quantitative testing (MQT). Immunotherapy promotes immunomodulation that occurs over several years. Quantitative testing offers the advantage of initiating immunotherapy with robust antigen concentrations. This study assessed whether changes in immune mediators and allergy symptoms occur rapidly using quantitative techniques. Sixteen allergic adults were tested using MQT. Subjects had serum drawn for immunoglobulins E and G4 (IgE, IgG4) to 3 antigens, Der p1, Der f1, and Fel d1, and for interleukins IL-1beta, IL-2, IL-4, IL-5, IL-10, IL-12, and IL-13, and IL-1 receptor antagonist (IL-1RA). Subjects also completed the Sino-Nasal Outcome Test-20 (SNOT-20), the Allergy Outcome Scale (AOS), and the Rhinosinusitis Disability Index (RSDI). They underwent MQT-based immunotherapy and completed outcome measures again at 6 and 12 weeks. Nine subjects completed the study. Analysis demonstrated significant increases in IgG4 levels to all antigens, significant decreases in serum levels of IL-1beta and IL-5, and significant increases in levels of IL-1RA. Improvement was also noted in AOS and RSDI subscales. Immunotherapy based on MQT demonstrates significant changes in i...Continue Reading

References

Sep 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·E A PastorelloC Zanussi
Dec 1, 1992·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·B R Gordon
Feb 11, 1992·The Journal of Allergy and Clinical Immunology·Z K PengN F Adkinson
Nov 21, 1997·Archives of Otolaryngology--head & Neck Surgery·M S Benninger, B A Senior
Nov 5, 1999·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D S HurstD H Hunsaker
Nov 5, 1999·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·B J KemkerR E Gliklich
Feb 1, 2002·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jay F PiccirilloMichele L Richards
Oct 24, 2003·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·John H Krouse, Richard L Mabry
Dec 4, 2004·The Journal of Allergy and Clinical Immunology·Anil NandaHarold S Nelson
Feb 4, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jacques Peltier, Matthew W Ryan

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Citations

May 31, 2011·Otolaryngologic Clinics of North America·Yekaterina A Koshkareva, John H Krouse
Sep 4, 2014·International Forum of Allergy & Rhinology·John A Fornadley
May 13, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Berrylin J Ferguson
Feb 14, 2018·International Forum of Allergy & Rhinology·Sarah K WiseMark Zacharek

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Methods Mentioned

BETA
blood drawn

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