Modulation of immune responses with monoclonal antibodies. I. Effects on regional lymph node morphology and on anti-hapten responses to haptenized monoclonal antibodies

European Journal of Immunology
S Mjaaland, S Fossum

Abstract

Repeated injections of monoclonal antibody (mAb) culture supernatants into rat footpads increased the weights of the draining lymph nodes. Immunostained freeze sections showed that injection of MRC OX2, a mAb reacting with rat follicular dendritic cells and MRC OX7 (anti-Thy-1.1), led to gross hypertrophy primarily of the follicular areas, whereas MRC OX6 (anti-rat major histocompatibility complex class II molecules) resulted in selective stimulation of the paracortex. These findings indicate that mAb, when conjugated to certain antigens, would modulate the immune response to these antigens. Consequently, the mAb were conjugated with fluorescein isothiocyanate (FITC) and the humoral response against the hapten measured. The primary anti-FITC antibody response was tenfold stronger than after stimulation with FITC conjugated to a conventional carrier such as ovalbumin, and had some characteristics of a secondary response: a fast increase of IgG level to very high titers and a long duration without further amplification at later antigen challenges.

References

Jun 1, 1979·European Journal of Immunology·W R McMaster, A F Williams
Jan 1, 1990·Immunology Today·L Adorini, Z A Nagy
Jan 1, 1989·Annual Review of Immunology·H Waldmann
Apr 1, 1980·The Biochemical Journal·D W Mason, A F Williams
Oct 1, 1980·The Journal of Experimental Medicine·M C NussenzweigZ A Cohn
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·W E KlinkertW E Bowers

❮ Previous
Next ❯

Citations

Oct 3, 2003·Journal of Molecular Recognition : JMR·Eszter MolnárAnna Erdei
Sep 28, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gunnveig GrodelandBjarne Bogen
Aug 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gunnveig GrodelandBjarne Bogen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.