PMID: 6970800Mar 1, 1981Paper

Modulation of immunoglobulin M and G synthesis by monocytes and T lymphocytes in the newborn infant

The Journal of Pediatrics
A C Ferguson, S S Cheung

Abstract

The role of peripheral blood T lymphocytes and monocytes in modulating Ig synthesis by B lymphocytes stimulated to become Ig-secreting plasma cells by pokeweed mitogen was studied using a sensitive enzyme-linked immunosorbent assay of IgM and IgG in healthy newborn infants and in adult controls. Neonates' B lymphocytes alone synthesized 20 to 30 times less Ig than adults' cells. Increasing proportions of autologous adults' T lymphocytes relative to B lymphocytes initially enhanced and then suppressed Ig synthesis, whereas autologous infants' T lymphocytes had no significant effect. Neonates' T lymphocytes cultured with adults' B lymphocytes enhanced and suppressed Ig synthesis comparably to adults' T lymphocytes, but neonates' B lymphocytes responded poorly to the helper effect of adults' T lymphocytes. Adults' monocytes diminished the helper and increased the suppressor effect of adults' and infants' T lymphocytes on adults' B lymphocytes, whereas neonates' monocytes cultured with neonates' T lymphocytes suppressed synthesis of IgG by neonates' B lymphocytes but had no effect on IgM. The findings suggest that the low serum Ig levels of the newborn period result primarily from immaturity of B lymphocytes rather than from T lymp...Continue Reading

References

May 1, 1976·The Journal of Pediatrics·R M Albrecht, R Hong

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Citations

Mar 30, 2006·Journal of Perinatology : Official Journal of the California Perinatal Association·M Ojeda-UribeA Brunot
Mar 1, 1982·Clinical Immunology and Immunopathology·M M EiblR Ahmad

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