Modulation of immunological abnormalities of growth hormone-deficient children by growth hormone treatment

Acta Paediatrica Japonica; Overseas Edition
M MatsuuraS Tanaka

Abstract

We studied the immunomodulatory role of growth hormone (GH) treatment in GH-deficient children. GH potentiated natural killer (NK)-cell activity and the PHA and Con-A lymphocytoproliferative response. Two-color fluorescence using monoclonal antibodies (CD4, 2H4, CD8 and CD11) showed a moderate reduction of the helper T cells and NK cells, but no changes of suppressor T cells or cytotoxic T-cells during GH therapy. Cancer and slow viral infection in GH-deficient children have been watched for carefully before and after GH therapy.

References

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Citations

Jul 1, 1992·Baillière's Clinical Endocrinology and Metabolism·J R Bierich
Dec 24, 1997·Acta Paediatrica. Supplement·R G Rapaport, M Bozzola
Oct 4, 2000·Pediatric Annals·H Anhalt, D Chin

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