PMID: 8956009Oct 1, 1996Paper

Modulation of in vivo neuronal sprouting by serotonin in the adult CNS of the snail

Cellular and Molecular Neurobiology
M W Baker, R P Croll

Abstract

1. During in situ recovery from a lesion to the cerebrobuccal connective (CBC) in the snail Achatina fulica, neurons of the buccal ganglia undergo extensive regeneration and sprouting as assessed by axonal dye-fillings of the CBC. 2. These changes are preceded by the distal degeneration of severed fibres from the serotonergic metacerebral giant neuron (MCG), which results in the depletion of serotonin (5-HT) in the ipsilateral buccal ganglion. We have investigated the potential role of this depletion in causing some of the ensuing neuroplastic events. 3. Pharmacological depletion of 5-HT using either 5,7-dihydroxtryptamine or p-chlorophenylalanine in normal, unlesioned animals was found to produce supernumerary neuronal labelling similar to that seen following a lesion. 4. Systemic daily injections of 5-HT were found to partly suppress the sprouting response following the CBC lesion. For example, the contralateral, uninjured MCG which is normally induced by the lesion to sprout novel projections into the denervated ganglion, is suppressed from doing so by the 5-HT treatment. 5. These growth inhibiting effects of 5-HT upon the contralateral MCG could be antagonized by the prior administration of the 5-HT receptor blocker cyprohe...Continue Reading

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Citations

Jun 22, 2000·Microscopy Research and Technique·S B Moffett
Oct 27, 2010·Cell and Tissue Research·Tim WollesenAndreas Wanninger
Dec 4, 1998·Biological Psychiatry·J A LiebermanJ E Kraus
Oct 31, 1998·Brain Research. Brain Research Reviews·A M DupratL Gualandris-Parisot
Oct 29, 2009·Arthropod Structure & Development·Silke Krüger, Reinhard Lakes-Harlan
Feb 15, 2005·Journal of Affective Disorders·Rif S Ei-Mallakh, Anoop Karippot
Nov 17, 2005·Development, Growth & Differentiation·Yasuko YoshiiSetsunosuke Ihara
Feb 14, 2007·Japanese Journal of Ophthalmology·Hiroshi TakahashiMasamichi Ishizaki
Jan 26, 2007·Journal of the Royal Society, Interface·Anthony D Metcalfe, Mark W J Ferguson
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Jun 13, 2006·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Steven McDougallPhilip Maini
May 22, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Judith A MackEric J Stelnicki
Mar 22, 2020·International Journal of Molecular Sciences·Irina B DeryabinaKhalil L Gainutdinov
Mar 1, 2011·Irish Journal of Psychological Medicine·Rif S El-MallakhAnton Surja

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