Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy.

Nano Letters
Parmeswaran DiagaradjaneSunil Krishnan

Abstract

We report noninvasive modulation of in vivo tumor radiation response using gold nanoshells. Mild-temperature hyperthermia generated by near-infrared illumination of gold nanoshell-laden tumors, noninvasively quantified by magnetic resonance temperature imaging, causes an early increase in tumor perfusion that reduces the hypoxic fraction of tumors. A subsequent radiation dose induces vascular disruption with extensive tumor necrosis. Gold nanoshells sequestered in the perivascular space mediate these two tumor vasculature-focused effects to improve radiation response of tumors. This novel integrated antihypoxic and localized vascular disrupting therapy can potentially be combined with other conventional antitumor therapies.

References

Dec 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y IshiharaY Suzuki
Mar 1, 1997·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M R Horsman, J Overgaard
Apr 7, 2000·The American Journal of Pathology·H HashizumeD M McDonald
Feb 22, 2001·Journal of the National Cancer Institute·M Höckel, P Vaupel
Apr 17, 2001·International Journal of Radiation Biology·H H Kampinga, E Dikomey
Nov 10, 2001·Annual Review of Biomedical Engineering·R K Jain
Mar 21, 2002·Nature Reviews. Cancer·Adrian L Harris
Sep 3, 2002·Advanced Drug Delivery Reviews·Irène BriggerPatrick Couvreur
Jun 5, 2003·Nature Medicine·Donald M McDonald, Peter L Choyke
Oct 28, 2003·The American Journal of Pathology·Peter BalukDonald M McDonald
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·L R HirschJ L West
Apr 2, 2004·Expert Review of Anticancer Therapy·Dietmar W Siemann, Michael R Horsman
May 26, 2004·Cancer Letters·D Patrick O'NealJennifer L West
Jun 16, 2004·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·J L Roti Roti
Oct 29, 2004·Physics in Medicine and Biology·James F HainfeldHenry M Smilowitz
May 24, 2005·Optics Letters·Christopher LooRebekah Drezek
Jun 2, 2005·Nature Reviews. Cancer·Gillian M TozerBruce C Baguley
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Dietmar W Siemann, Amyn M Rojiani
Jul 28, 2005·Lasers in Surgery and Medicine·Andre M GobinJennifer L West
Sep 8, 2005·Journal of the National Cancer Institute·Leslie Harris O'Hanlon
Apr 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Willem J van HeeckerenScot C Remick
Sep 13, 2006·Journal of Biomedical Optics·Anant AgrawalT Joshua Pfefer
Oct 6, 2006·Cancer Chemotherapy and Pharmacology·M B JamesonUNKNOWN Cancer Research (UK) Phase I/II Trials Committee
Feb 1, 2007·Journal of the American Chemical Society·Chia-Hao SuChen-Sheng Yeh
Feb 7, 2007·Medical Physics·Eduardo G MorosColin G Orton
Mar 22, 2007·British Journal of Cancer·P Hinnen, F A L M Eskens
Mar 24, 2007·Nanomedicine : Nanotechnology, Biology, and Medicine·Huan XieD Patrick O'Neal
Apr 19, 2007·Cancer Metastasis Reviews·Benjamin J MoellerMark W Dewhirst
Apr 27, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·D M Patterson, G J S Rustin
Jun 5, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ruud P M DingsRobert J Griffin
Oct 16, 2007·Current Opinion in Hematology·Willem J van HeeckerenScot C Remick
Nov 14, 2007·Methods in Enzymology·J Martin Brown

❮ Previous
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Citations

Mar 11, 2010·Breast Cancer Research and Treatment·Laura B CarpinRebekah A Drezek
Oct 17, 2009·Journal of Materials Science. Materials in Medicine·Shun-Ying LiuGuo-Quan Lu
Nov 26, 2010·Pharmaceutical Research·Sanjib BhattacharyyaPriyabrata Mukherjee
Apr 29, 2010·Current Oncology Reports·Ivan H El-Sayed
Jul 23, 2013·Advances in Colloid and Interface Science·Mohammed S Khan Siddaramaiah H
May 27, 2011·Accounts of Chemical Research·Rizia BardhanNaomi J Halas
Oct 7, 2011·Molecular Pharmaceutics·Ruth Duncan, Rogerio Gaspar
Jul 10, 2009·Chemical Society Reviews·Elodie Boisselier, Didier Astruc
Aug 5, 2009·Chemical Communications : Chem Comm·Wen-Shuo KuoChen-Sheng Yeh
Aug 3, 2011·Chemical Communications : Chem Comm·Francesca MastrottoStefano Salmaso
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ji-Ho ParkMichael J Sailor
Dec 24, 2011·Journal of Biomedical Optics·Guangying GuanRuikang K Wang
Oct 29, 2010·Science Translational Medicine·Rachel L AtkinsonJeffrey M Rosen
Mar 23, 2011·International Journal of Nanomedicine·Huan XieSunil Krishnan
Nov 25, 2011·International Journal of Nanomedicine·Alsayed A M ElsherbiniHesham A A Shokier
Jan 1, 2014·International Journal of Nanomedicine·Katarzyna PalaJacek Otlewski
Dec 25, 2010·Nanomedicine·Christine VauthierPatrick Couvreur
Apr 17, 2012·Therapeutic Delivery·Dev Kumar ChatterjeeSunil Krishnan
Nov 1, 2012·Biotechnology Advances·Anil KumarXing-Jie Liang
Oct 25, 2014·Nanomedicine·Jun ZhaoMarites P Melancon
May 2, 2009·Journal of Biomedical Optics·Priyaveena PuvanakrishnanJames W Tunnell
May 2, 2009·Journal of Biomedical Optics·Georgy S TerentyukValery V Tuchin
Mar 10, 2010·Journal of Biomedical Optics·Glenn P GoodrichJ Donald Payne
Nov 22, 2011·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·R Jason StaffordJohn D Hazle
Sep 23, 2010·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Sunil KrishnanSang Hyun Cho
Jul 16, 2011·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·D FuentesR J Stafford
Jan 14, 2016·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Punit KaurSunil Krishnan
Sep 25, 2015·Expert Review of Anticancer Therapy·Edouard AlphandéryMickael Durand-Dubief
Dec 25, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Adam J GormleyHamidreza Ghandehari
Jun 28, 2012·Nano Today·Adam J GormleyHamidreza Ghandehari
Dec 30, 2015·Advanced Drug Delivery Reviews·Sohyoung HerChristine Allen
Jul 19, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marites P MelanconChun Li
Dec 3, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Duncan Hieu M DamTeri W Odom
Sep 23, 2010·Advanced Drug Delivery Reviews·Prakash RaiTayyaba Hasan
Nov 4, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ryan RobinsonHamidreza Ghandehari
Dec 25, 2015·International Journal of Radiation Oncology, Biology, Physics·Jan SchuemannSunil Krishnan
Sep 30, 2015·Nano Letters·Sijumon KunjachanRoss I Berbeco
Jun 28, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Mohan SinghDaniel S Elson
Mar 15, 2011·Lasers in Surgery and Medicine·Jaesook ParkJames W Tunnell
May 10, 2015·The AAPS Journal·Aaron C Anselmo, Samir Mitragotri

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