PMID: 8451291Feb 1, 1993Paper

Modulation of interferon-gamma-induced HLA-DR expression on the human keratinocyte cell line SCC-13 by ultraviolet radiation

Photochemistry and Photobiology
I U KhanC A Elmets

Abstract

Cell surface expression of major histocompatibility determinants on epidermal keratinocytes is a characteristic feature of a number of inflammatory dermatoses and in all likelihood is caused by diffusion of human leukocyte antigen (HLA)-DR-inducing cytokines from cells present in the dermal mononuclear cell infiltrate. Many of these same disorders respond to ultraviolet (UV) radiation phototherapy. Using the human SCC-13 keratinocyte cell line as a model, UV radiation was found to inhibit interferon-gamma-induced HLA-DR expression. Inhibition correlated closely with decreased steady-state levels of HLA-DR mRNA. These findings provide evidence that the therapeutic effect of UV radiation phototherapy may be mediated by its capacity to down-regulate cytokine-induced keratinocyte HLA-DR expression.

References

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Citations

Oct 3, 1998·Journal of Photochemistry and Photobiology. B, Biology·J Krutmann
Dec 22, 1999·The Proceedings of the Nutrition Society·D A Hughes
Nov 18, 2003·Photodermatology, Photoimmunology & Photomedicine·M R PraterS D Holladay
Mar 1, 1997·The Journal of Laboratory and Clinical Medicine·D A HughesS Southon

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