Modulation of interhemispheric activation balance in motor-related areas of stroke patients with motor recovery: Systematic review and meta-analysis of fMRI studies

Neuroscience and Biobehavioral Reviews
Qing TangQiwen Mu

Abstract

Functional magnetic resonance imaging (fMRI) studies suggest that stroke-induced motor deficits are associated with an interhemispheric imbalance of motor activation. This meta-analysis aims to determine the changes of interhemispheric activation balance (IHAB) in motor-related cortices along with post-stroke motor recovery. We searched PubMed for fMRI studies that investigated IHAB in stroke patients with motor recovery. Laterality indexes (LIs, (ipsilesional activation-contralesional activation)/(ipsilesional activation+contralesional activation)) before and after motor improvement were extracted as the outcome measures of IHAB. Data were synthesized by calculating standardized mean difference (SMD, Hedges' adjusted g) with 95% confidence intervals (CI). After the rejection of 459 studies, 22 trials fulfilled the inclusion criteria and were included in the systematic review and meta-analysis. The LIs of sensorimotor cortex (SMC, 22 trials, 195 subjects), premotor cortex (PMC, 12 trials, 93 subjects), supplementary motor area (SMA, 12 trials, 92 subjects), and cerebellum (CB, 4 trials, 31 subjects) were assessed. Studies sampling from stroke patients with motor improvement showed positive changes of LI in SMC (SMD, 0.71; 95% C...Continue Reading

References

Mar 4, 2000·Stroke; a Journal of Cerebral Circulation·R S MarshallR L DeLaPaz
Apr 17, 2001·Annals of Internal Medicine·D MoherUNKNOWN CONSORT GROUP (Consolidated Standards of Reporting Trials)
Sep 28, 2001·Journal of the American Podiatric Medical Association·D MoherUNKNOWN CONSORT Group (Consolidated Standards of Reporting Trials)
Nov 28, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·S J Boniface
Mar 26, 2002·Brain : a Journal of Neurology·James R CareyKamil Ugurbil
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Jul 12, 2002·Statistics in Medicine·Simon G Thompson, Julian P T Higgins
Oct 12, 2002·Proceedings of the National Academy of Sciences of the United States of America·Heidi Johansen-BergPaul M Matthews
Dec 5, 2002·Neurorehabilitation and Neural Repair·Judith D SchaechterSteven C Cramer
Jan 23, 2003·Seminars in Neurology·Edward J FineLinda Lohr
May 10, 2003·Stroke; a Journal of Cerebral Circulation·Cinzia Calautti, Jean-Claude Baron
Aug 26, 2003·Brain : a Journal of Neurology·N S WardR S J Frackowiak
Jun 3, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mervi KönönenIna M Tarkka
Apr 29, 2006·Stroke; a Journal of Cerebral Circulation·Yun DongCarolee J Winstein
Dec 5, 2006·Archives of Physical Medicine and Rehabilitation·Andrew J Butler, Stephen J Page
Nov 17, 2007·Journal of Child Neurology·Trenna L SutcliffeDarcy L Fehlings
Sep 25, 2009·The Journal of Neuropsychiatry and Clinical Neurosciences·Uri WolfTom A Schweizer
May 5, 2010·Neurorehabilitation and Neural Repair·Floor E BumaGert Kwakkel
Nov 6, 2010·Neurorehabilitation and Neural Repair·Marian E MichielsenJohannes B J Bussmann
Mar 29, 2011·Stroke; a Journal of Cerebral Circulation·Chang-hyun ParkYun-Hee Kim
May 4, 2011·Statistics in Medicine·Hathaikan ChootrakoolRongxian Yue
Nov 2, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M KönönenR Vanninen
Feb 16, 2012·Journal of Rehabilitation Medicine·Othmar SchuhfriedTatjana Paternostro-Sluga
Mar 13, 2012·Translational Stroke Research·Rick M DijkhuizenMaurits P A van Meer
Mar 16, 2013·Annals of Neurology·Ander Ramos-MurguialdayNiels Birbaumer
Apr 2, 2013·Clinical Rehabilitation·Sheila LennonFiona Jones
Apr 26, 2013·Disability and Rehabilitation. Assistive Technology·Marcela Cavalcanti MoreiraMarco Aurélio Benedetti Rodrigues
Jun 6, 2013·Stroke Research and Treatment·Naoyuki Takeuchi, Shin-Ichi Izumi
Jun 20, 2013·Stroke; a Journal of Cerebral Circulation·Christopher L H ChenUNKNOWN CHIMES Study Investigators
Jul 12, 2013·Topics in Stroke Rehabilitation·Felipe Orihuela-EspinaLuis Enrique Sucar
Jan 11, 2014·Progress in Neurobiology·Fan ChenXunming Ji
Jan 17, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amanda V UtevskyScott A Huettel

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Citations

Jul 5, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Clément BrunnerJean-Claude Baron
Oct 7, 2017·Frontiers in Human Neuroscience·Keith C DoddVivek Prabhakaran
Jan 13, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Layla GouldRon Borowsky
Mar 2, 2021·Frontiers in Aging Neuroscience·Ting ShenHsin-Yi Lai
Aug 31, 2021·Neural Plasticity·Jinhuan ZhangHaibo Yu

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