Modulation of Interparticle Distance in Discrete Gold Nanoparticle Dimers and Trimers by DNA Single-Base Pairing

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Yoshitsugu AkiyamaMizuo Maeda

Abstract

Self-assembled structures of metallic nanoparticles with dynamically changeable interparticle distance hold promise for the regulation of collective physical properties. This paper describes gold nanoparticle dimers and trimers that exhibit spontaneous and reversible changes in interparticle distance. To exploit this property, a gold nanoparticle is modified with precisely one long DNA strand and approximately five short DNA strands. The long DNA serves to align the nanoparticles on a template DNA via hybridization, while the short DNAs function to induce the interparticle distance changes. The obtained dimer and trimer are characterized with gel electrophoresis, dynamic light scattering measurements, and transmission electron microscopy (TEM). When the complementary short DNA is added to form the fully matched duplexes on the particle surface in the presence of MgCl2 , spontaneous reduction of the interparticle distance is observed with TEM and cryo-electron microscopy. By contrast, when the terminal-mismatched DNA is added, no structural change occurs under the same conditions. Therefore, the single base pairing/unpairing at the outermost surface of the nanoparticle impacts the interparticle distance. This unique feature coul...Continue Reading

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Citations

Jun 30, 2015·Nano Letters·Tianhong ChenBjörn M Reinhard
Jul 21, 2015·Journal of the American Chemical Society·Pascal K HarimechAntonios G Kanaras
Oct 27, 2020·Chemical Communications : Chem Comm·Naoki KanayamaMizuo Maeda
Dec 8, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hiroya NakauchiNaoki Kanayama
Oct 20, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Zhiyu HeMizuo Maeda
Mar 9, 2021·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Akane MukaidaMasao Kamimura
Jun 16, 2021·Soft Matter·Ahmad MoghimikheirabadiArgyrios V Karatrantos
Dec 14, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Naoki KanayamaMizuo Maeda
Mar 30, 2019·ACS Applied Materials & Interfaces·Yuxi ZhanYunfeng Lin
May 8, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Tzung-Ying YangMizuo Maeda

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