Modulation of intestinal vitamin D receptor availability and calcium ATPase activity by essential fatty acids

Prostaglandins, Leukotrienes, and Essential Fatty Acids
F LeonardMarlena C Kruger

Abstract

The physiological mechanisms by which essential fatty acids (EFAs) affect calcium (Ca(2+)) retention is not clear, but suggestions have included changes in membrane fluidity, receptor modulation and induction of second messengers. The vitamin D receptor (VDR) is essential for the functioning of 1,25(OH)(2)D(3)which increases Ca(2+)absorption. Activity of the intestinal basolateral membrane (BLM) Ca(2+)ATPase correlates with the degree of Ca(2+)absorption. Therefore, changes in ATPase activity and VDR availability due to EFAs may influence calcium retention. We have investigated the effect of long-term dietary supplementation with EFAs on Ca(2+)ATPase activity (measured colourimetrically) and VDR availability (measured with the ELISA technique) after the loss of oestrogen induced by ovariectomy (OVX) in female Sprague Dawley rats. Control animals underwent anaesthesia and a surgical procedure but the ovaries were left intact (sham). Ca(2+)ATPase activity was significantly lower in OVX animals than in the intact animals (P<0.05) and following supplementation with EFAs, was significantly higher than in sham controls (P<0.05). A higher number of VDR was measured after OVX and declined due to EFA supplementation; these differences i...Continue Reading

References

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Citations

May 25, 2012·The British Journal of Nutrition·Tonya S OrchardRebecca D Jackson
Oct 16, 2007·Journal of Morphology·Katharina RinerAnnette Liesegang
Jun 27, 2006·Domestic Animal Endocrinology·A LiesegangA Boos
Apr 23, 2011·Lipids in Health and Disease·Afaf K El-AnsaryLayla Y Al-Ayahdi
Jan 21, 2014·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Tony DudognonEdouard Kraffe
Aug 25, 2001·Prostaglandins & Other Lipid Mediators·M HaagM C Kruger
Jun 12, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Marianne HaagMarlena C Kruger

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