Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential

Nature
Yousheng ShuDavid A McCormick

Abstract

Traditionally, neuronal operations in the cerebral cortex have been viewed as occurring through the interaction of synaptic potentials in the dendrite and soma, followed by the initiation of an action potential, typically in the axon. Propagation of this action potential to the synaptic terminals is widely believed to be the only form of rapid communication of information between the soma and axonal synapses, and hence to postsynaptic neurons. Here we show that the voltage fluctuations associated with dendrosomatic synaptic activity propagate significant distances along the axon, and that modest changes in the somatic membrane potential of the presynaptic neuron modulate the amplitude and duration of axonal action potentials and, through a Ca2+-dependent mechanism, the average amplitude of the postsynaptic potential evoked by these spikes. These results indicate that synaptic activity in the dendrite and soma controls not only the pattern of action potentials generated, but also the amplitude of the synaptic potentials that these action potentials initiate in local cortical circuits, resulting in synaptic transmission that is a mixture of triggered and graded (analogue) signals.

References

May 1, 1975·The Journal of Physiology·T Shimahara, L Tauc
Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M B JacksonG J Augustine
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E ShapiroE R Kandel
Dec 1, 1995·Neuron·Z F MainenT J Sejnowski
Feb 11, 1998·The Journal of Physiology·G StuartB Sakmann
Jun 8, 1999·The Journal of Physiology·D FrickerR Miles
Aug 10, 2000·Proceedings of the National Academy of Sciences of the United States of America·C L CoxK Svoboda
Oct 4, 2000·Nature Neuroscience·M V Sanchez-Vives, D A McCormick
May 16, 2001·Journal of Neurophysiology·M SteriadeF Grenier
May 16, 2003·Nature·Yousheng ShuDavid A McCormick
Oct 29, 2003·Neurology·K M A Welch
Jul 9, 2004·Cerebral Cortex·Tom BinzeggerKevan A C Martin
Oct 1, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tom BinzeggerKevan A C Martin
Mar 4, 2006·Science·Henrik Alle, Jörg R P Geiger

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Citations

Sep 3, 2010·Pflügers Archiv : European journal of physiology·Itzchak Parnas, Hanna Parnas
Nov 28, 2012·Journal of Computational Neuroscience·Nir GrossmanKonstantin Nikolic
Jul 27, 2012·Neuroscience Bulletin·Wenqin Hu, Yousheng Shu
Apr 8, 2009·Nature Neuroscience·Kenneth Paradiso, Ling-Gang Wu
Dec 21, 2010·Nature Neuroscience·Jason M ChristieCraig E Jahr
Jun 5, 2012·Nature Neuroscience·Stefan HallermannMaarten H P Kole
Aug 1, 2006·Nature Neuroscience·Kirill E VolynskiDimitri M Kullmann
Sep 10, 2009·Cerebral Cortex·Alvaro Duque, David A McCormick
Nov 19, 2010·Cerebral Cortex·Fu-Wen Zhou, Steven N Roper
Feb 5, 2011·Science·Takuya SasakiYuji Ikegaya
Jul 12, 2013·Annual Review of Neuroscience·Guy MajorJackie Schiller
May 20, 2011·Journal of Neurophysiology·Colin G EvansElizabeth C Cropper
Jul 17, 2009·Journal of Neurophysiology·Bjoern Ch LudwarElizabeth C Cropper
Mar 24, 2012·Journal of Neurophysiology·Thomas J FoutzCameron C McIntyre
Dec 17, 2009·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Brian D ClarkBernardo Rudy
Feb 22, 2012·Neural Development·Michael P SceniakShasta L Sabo
Jan 28, 2014·PLoS Computational Biology·Biswa SenguptaJeremy Edward Niven
May 9, 2014·PLoS Computational Biology·Ali Neishabouri, A Aldo Faisal
Aug 2, 2007·PloS One·Ramon Reig, Maria V Sanchez-Vives
Aug 1, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ricardo ScottDmitri A Rusakov
Jul 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuguo YuDavid A McCormick
Sep 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dario J EnglotHal Blumenfeld
Jul 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ryan M DrenanHenry A Lester
Oct 5, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·YunXiang ChuWade G Regehr
Oct 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Esther Krook-MagnusonIvan Soltesz
Jul 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Colin G EvansElizabeth C Cropper
Sep 18, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason M Christie, Craig E Jahr
Sep 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuguo YuDavid McCormick
Oct 28, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amanda J FoustDavid A McCormick
Oct 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shunbing ZhaoFarzan Nadim
Nov 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason R Pugh, Craig E Jahr
Feb 29, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel J Brasier, Daniel E Feldman
Nov 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew S GrubbKevin J Bender
Jan 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason R Pugh, Craig E Jahr
Jan 21, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sina TootoonianMala Murthy

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