PMID: 11323133Apr 27, 2001Paper

Modulation of jaw muscle spindle afferent activity following intramuscular injections with hypertonic saline

Pain
J Y Ro, Norman F Capra

Abstract

Transient noxious chemical stimulation of small diameter muscle afferents modulates jaw movement-related responses of caudal brainstem neurons. While it is likely that the effect is mediated from the spindle afferents in the mesencephalic nucleus (Vmes) via the caudally projecting Probst's tract, the mechanisms of pain induced modulations of jaw muscle spindle afferents is not known. In the present study, we tested the hypothesis that jaw muscle nociceptors gain access to muscle spindle afferents in the same muscle via central mechanisms and alter their sensitivity. Thirty-five neurons recorded from the Vmes were characterized as muscle spindle afferents based on their responses to passive jaw movements, muscle palpation, and electrical stimulation of the masseter nerve. Each cell was tested by injecting a small volume (250 microl) of either 5% hypertonic and/or isotonic saline into the receptor-bearing muscle. Twenty-nine units were tested with 5% hypertonic saline, of which 79% (23/29) showed significant modulation of mean firing rates (MFRs) during one or more phases of ramp-and-hold movements. Among the muscle spindle primary-like units (n = 12), MFRs of 4 units were facilitated, five reduced, two showed mixed responses and...Continue Reading

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Citations

Sep 29, 2009·Neuroscience Bulletin·Umar AliHao-Jun You
May 12, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·K WangL Arendt-Nielsen
Feb 1, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·T HilbergW Schramm
Jan 28, 2009·Cephalalgia : an International Journal of Headache·A PeddireddyL Arendt-Nielsen
Mar 12, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Heidi L LujanStephen E DiCarlo
Nov 24, 2011·Pain Research and Treatment·Dean Dessem, Richard M Lovering
Feb 12, 2004·European Journal of Oral Sciences·Per-Olof ErikssonBirgitta Häggman-Henrikson
Nov 28, 2006·Archives of Oral Biology·Norman F CapraRadi M Masri
Jan 1, 2004·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·S O'LearyG Jull
May 17, 2003·Pain·Michele SterlingRoss Darnell
Dec 17, 2014·Human Movement Science·Christian A MistaThomas Graven-Nielsen
Jun 19, 2016·Archives of Physical Medicine and Rehabilitation·Matthew Hoyan TongJaap van Dieën
Aug 31, 2002·Journal of Dental Research·K WangP Svensson
Nov 28, 2009·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Hong-You GeLars Arendt-Nielsen
Oct 31, 2002·Journal of Dental Research·B Häggman-HenriksonP-O Eriksson
Oct 5, 2007·Brain Research Reviews·Nikolai E Lazarov

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