Modulation of laser-evoked potentials by experimental cutaneous tonic pain

Neuroscience
M ValerianiM Tinazzi

Abstract

The present study aimed to investigate whether tonic cutaneous pain exerts any effect on the cortical processing of nociceptive input and if this effect may involve only body parts in pain. Tonic cutaneous pain was obtained in nine healthy human subjects by infusion of a hypertonic saline (5%) in the s.c. tissue over the hypothenar muscles (10 ml/h for 20 min). Nociceptive cutaneous CO2 laser-evoked potentials were recorded after stimulation of the right hand dorsum, which was adjacent to the painful area, and the right perioral region, corresponding to the adjacent cortical sensory area. Laser-evoked potentials were obtained before saline injection, at the peak pain and 20 min after pain disappeared. During saline infusion, the laser-evoked pain to right hand stimulation was reduced and the vertex laser-evoked potentials (N2a-P2, mean latency 181 ms and 319 ms for the N2a and the P2 potentials, respectively), which are generated in the anterior cingulate cortex, were significantly decreased in amplitude compared with the baseline. Moreover, the topography of these potentials was modified by cutaneous pain, shifting from the central toward the parietal region. Dipolar modeling showed that the dipolar source in the anterior cing...Continue Reading

References

Jul 1, 1993·Electroencephalography and Clinical Neurophysiology·V Kunde, R D Treede
Oct 1, 1993·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·I M Tarkka, R D Treede
Jan 14, 1998·Neuroreport·L García-LarreaF Mauguière
Jun 10, 1998·Brain : a Journal of Neurology·M J IadarolaG J Bennett
Mar 27, 1999·Neurophysiologie clinique = Clinical neurophysiology·I MerletF Mauguière
May 29, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M FrotF Mauguière
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·K L Casey
Sep 1, 1999·Brain : a Journal of Neurology·R PeyronB Laurent
May 4, 2001·Brain : a Journal of Neurology·H OlaussonM C Bushnell
Sep 23, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Massimiliano ValerianiMichele Tinazzi
Dec 18, 2003·Neurophysiologie clinique = Clinical neurophysiology·L Garcia-LarreaM Valeriani
Nov 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·A Vania ApkarianDarren R Gitelman
Feb 8, 2005·Neuroscience Letters·Asbjørn Mohr DrewesMassimiliano Valeriani
Jun 28, 2005·European Journal of Pain : EJP·A Vania ApkarianJon-Kar Zubieta
Jul 5, 2005·Nature Reviews. Neuroscience·Brent A Vogt
Aug 23, 2005·NeuroImage·Christian Maihöfner, Hermann O Handwerker

❮ Previous
Next ❯

Citations

Nov 3, 2011·Experimental Brain Research·Line Lindhardt EgsgaardLars Arendt-Nielsen
May 1, 2009·Expert Review of Neurotherapeutics·Costanza Pazzaglia, Massimiliano Valeriani
Oct 4, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J L K KramerJ D Steeves
Apr 6, 2007·Gastroenterology·Georg DimcevskiAsbjørn M Drewes
Apr 15, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Lisa GoudmanMargot De Kooning

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.