PMID: 10707323Mar 9, 2000Paper

Modulation of leptin sensitivity by short photoperiod acclimation in the Djungarian hamster, Phodopus sungorus

Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
M KlingensporG Heldmaier

Abstract

During seasonal acclimation, Djungarian hamsters spontaneously exhibit a reduction in food intake, body mass and body fat stores, which is externally cued by shortening of day length in autumn and controlled by a sliding set-point. We investigated the function of the leptin adipostatic feedback system in the photoperiodic control of seasonal acclimation. In response to mouse recombinant leptin injections for 10 days, long day photoperiod (LD) and short day photoperiod (SD)-acclimated hamsters decreased food intake and body mass. The reduction of body mass was due to the depletion of body fat, as revealed by carcass composition analysis. In SD hamsters, leptin caused a larger reduction of body fat mass than observed under LD conditions, whereas the anorectic effect was similar in both photoperiods. The serum leptin concentration was 9.3 +/- 1.2 ng/ml in LD-acclimated hamsters and decreased significantly to 4.2 +/- 0.8 ng/ml and 2.1 +/- 0.6 ng/ml in hamsters exposed to SD for 66 days and 116 days, respectively (P < 0.001). A strong positive correlation between total body fat mass and serum leptin concentration was found (rS = 0.935, P < 0.0001, n = 70). Despite the anorectic action of exogenous leptin, higher endogenous leptin le...Continue Reading

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