PMID: 9178632Jul 1, 1997Paper

Modulation of ligand-gated dopamine channels in Helix neurones

Pflügers Archiv : European journal of physiology
K A Green, G A Cottrell

Abstract

Dopamine gates a fast excitatory response in Helix C2 neurones. Whole cell, and multiple unitary dopamine-gated currents showed variable decay rates and desensitization properties, suggesting the presence of more than one channel type. Manipulation of internal free [Ca2+] by various procedures (external zero Ca2+ or 1 mM Co2+, prolonged depolarization, A23187, or flufenamic acid), affected both the amplitude and decay time for the response, and also suggested the presence of separate fast and slowly decaying components. Responses were prolonged by intracellular fluoride a non specific phosphatase inhibitor, and attenuated and shortened by the protein kinase inhibitors H7 and staurosporine, and the calmodulin inhibitor W7. Phorbol ester potentiated and prolonged the response and this effect was reversibly antagonized by the specific protein kinase C inhibitor chelerythrine. Different dopamine-activated unitary currents were distinguished in outside-out patches by conductance (5, 8, 12 and 15pS), rate of recovery from desensitization, and pattern of openings. Discrimination of slow and fast components of the response was possible with apomorphine, ADTN, and caffeine. Paradoxically the dopamine antagonists chlorpromazine and spipe...Continue Reading

Citations

Jun 17, 2011·Journal of Neurophysiology·Lolahon R KadiriRonald M Harris-Warrick
Dec 13, 2006·Experimental Neurology·Ming-Cheng Tsai, Yi-Hung Chen
May 30, 2006·Pharmacology, Biochemistry, and Behavior·Xuejiao ChenYanguo Hong
May 21, 2016·The Journal of Physiology·Raymond M Sturgeon, Neil S Magoski
Mar 10, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yaohui ZhuJan D Huizinga

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