Modulation of limbic-cerebellar functional connectivity enables alcoholics to recognize who is who.

Brain Structure & Function
Anne-Lise PitelEdith V Sullivan

Abstract

Chronic alcoholism is known to disrupt functions served by distributed brain systems, including limbic and frontocerebellar circuits involved in resting-state and task-activated networks subserving component processes of memory often affected in alcoholics. Using an fMRI paradigm, we investigated whether memory performance by alcoholics on a face-name association test previously observed to be problematic for alcoholics could be explained by desynchronous activity between nodes of these specific networks. While in the scanner, 18 alcoholics and 15 controls performed a face-name associative learning task with different levels of processing at encoding. This task was designed to activate the hippocampus, cerebellum, and frontal cortex. Alcoholics and controls were also scanned at rest. Twelve alcoholics and 12 controls were selected to be matched on face-name recognition performance. Task-related fMRI analysis indicated that alcoholics had preserved limbic activation but lower cerebellar activation (Crus II) than the controls in the face-name learning task. Crus II was, therefore, chosen as a seed for functional connectivity MRI analysis. At rest, the left hippocampus and left Crus II had positively synchronized activity in contr...Continue Reading

References

Jan 1, 1990·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·C G Harper, J J Kril
Feb 1, 1988·Alcoholism, Clinical and Experimental Research·A PfefferbaumT L Jernigan
Apr 1, 1987·The Journal of Nervous and Mental Disease·K W Schaeffer, O A Parsons
Jun 1, 1982·Journal of Abnormal Psychology·H A Skinner, B A Allen
Nov 1, 1982·Journal of Studies on Alcohol·H A Skinner, W J Sheu
Feb 1, 1995·Alcoholism, Clinical and Experimental Research·E V SullivanA Pfefferbaum
Mar 2, 1999·Brain : a Journal of Neurology·J DrepperH C Diener
Apr 28, 2000·The American Journal of Psychiatry·M D De BellisM S Keshavan
Feb 24, 2001·Acta Psychologica·R L BucknerM E Wheeler
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Apr 3, 2001·Nature Reviews. Neuroscience·F VarelaJ Martinerie
May 4, 2001·Brain : a Journal of Neurology·P C Fletcher, R N Henson
Oct 5, 2001·Nature Reviews. Neuroscience·A K EngelW Singer
Sep 10, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael D RuggRichard N A Henson
Feb 28, 2003·Alcoholism, Clinical and Experimental Research·Edith V SullivanAdolf Pfefferbaum
Mar 9, 2004·Neuron·Eve De RosaEdith V Sullivan
Apr 15, 2004·Human Brain Mapping·Tianzi JiangXuchu Weng
May 29, 2004·Neuroreport·Michelle HampsonJohn C Gore
Nov 6, 2004·Magnetic Resonance Imaging·Victoria L Morgan, Ronald R Price
Jan 12, 2005·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·Meredith Minear, Denise C Park
Feb 11, 2005·Journal of Studies on Alcohol·Susan F TapertChristina Burke
Apr 19, 2005·Psychopharmacology·Edith V Sullivan, Adolf Pfefferbaum
Oct 28, 2005·Nature Neuroscience·Barry J Everitt, Trevor W Robbins
Apr 12, 2006·PLoS Biology·Christopher SummerfieldJennifer Mangels
Jan 1, 1990·Drug and Alcohol Review·S C PhillipsJ J Kril
Oct 28, 2006·Alcoholism, Clinical and Experimental Research·Thomas P BeresfordChristos Davatzikos
Dec 22, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michelle HampsonR Todd Constable
May 22, 2007·Alcoholism, Clinical and Experimental Research·Anne Lise PitelFrancis Eustache
May 24, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Robert S Blumenfeld, Charan Ranganath
Aug 21, 2007·Nature Reviews. Neuroscience·Michael D Fox, Marcus E Raichle
Oct 9, 2007·Neuroscience and Biobehavioral Reviews·L E FitzpatrickS F Crowe
Apr 1, 2008·Biological Psychiatry·Nikos MakrisGordon J Harris
Apr 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Atsuko Nagano-SaitoAlain Dagher
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Nov 28, 2008·Brain : a Journal of Neurology·Eosu KimYoung-Chul Jung
Jul 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christophe HabasMichael D Greicius
Jul 31, 2009·Neuron·Bernhard P Staresina, Lila Davachi
Aug 14, 2009·Alcoholism, Clinical and Experimental Research·Ksenija MarinkovicGordon J Harris
Aug 28, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George F Koob, Nora D Volkow
Sep 25, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bradford C Dickerson, Howard Eichenbaum

❮ Previous
Next ❯

Citations

Jul 21, 2015·Developmental Cognitive Neuroscience·Anita CservenkaBonnie J Nagel
Nov 26, 2019·Journal of Neuroscience Research·Manon EddeSandra Chanraud
Jun 5, 2019·Brain Structure & Function·Rosemary FamaEdith V Sullivan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Imaging of Neural Circuits

Neural circuits are groups of interconnected neurons which carry out specific functions when activated. Imaging these neural circuits allows researches to further elucidate their mechanisms and functions. Follow this feed to stay up to date on brain imaging of neural circuits.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Brain Imaging of Neural Circuits (MDS)

Neural circuits are groups of interconnected neurons which carry out specific functions when activated. Imaging these neural circuits allows researches to further elucidate their mechanisms and functions. Follow this feed to stay up to date on brain imaging of neural circuits.