Modulation of macrophage efferocytosis in inflammation.

Frontiers in Immunology
Darlynn KornsD L Bratton

Abstract

A critical function of macrophages within the inflammatory milieu is the removal of dying cells by a specialized phagocytic process called efferocytosis ("to carry to the grave"). Through specific receptor engagement and induction of downstream signaling, efferocytosing macrophages promote resolution of inflammation by (i) efficiently engulfing dying cells, thus avoiding cellular disruption and release of inflammatory contents, and (ii) producing anti-inflammatory mediators such as IL-10 and TGF-β that dampen pro-inflammatory responses. Evidence suggests that plasticity in macrophage programming, in response to changing environmental cues, modulates efferocytic capability. Essential to programming for enhanced efferocytosis is activation of the nuclear receptors PPARγ, PPARδ, LXR, and possibly RXRα. Additionally, a number of signals in the inflammatory milieu, including those from dying cells themselves, can influence efferocytic efficacy either by acting as immediate inhibitors/enhancers or by altering macrophage programming for longer-term effects. Importantly, sustained inflammatory programming of macrophages can lead to defective apoptotic cell clearance and is associated with development of autoimmunity and other chronic i...Continue Reading

Citations

Apr 26, 2014·Future Microbiology·Heiko Bruns, Steffen Stenger
Aug 20, 2014·Nature Reviews. Rheumatology·Robert Lafyatis
May 23, 2014·Antioxidants & Redox Signaling·Laura KuchlerAndreas von Knethen
Dec 17, 2015·Annual Review of Physiology·Irina Petrache, Evgeny V Berdyshev
Feb 19, 2013·COPD·Vandana Gupta, Dave Singh
Nov 28, 2015·Nature Reviews. Drug Discovery·Johan Kreuger, Mia Phillipson
Jun 5, 2013·Chest·Alexandra L McCubbrey, Jeffrey L Curtis
Sep 29, 2015·Journal of Biomaterials Science. Polymer Edition·Purnima KumarYoshiki Katayama
Jun 25, 2013·The Journal of Pathology·James N FullertonDerek W Gilroy
Sep 26, 2012·The Journal of Pathology·Amiram Ariel, Orly Timor
Jun 26, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E A JacobsenJ J Lee
Oct 17, 2014·Immunological Reviews·Partha Dutta, Matthias Nahrendorf
Dec 25, 2012·Matrix Biology : Journal of the International Society for Matrix Biology·Colleen S Curran, Patricia J Keely
May 20, 2015·European Journal of Pharmacology·Hosana G RodriguesMarco A R Vinolo
Nov 7, 2014·Cell Reports·Alexander V MisharinHarris Perlman
Mar 19, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Susanne M OhlssonThomas Hellmark
Mar 4, 2014·Current Opinion in Microbiology·Constance J MartinSamuel M Behar
Nov 17, 2012·The Journal of Allergy and Clinical Immunology·Ruby Fernandez-BoyanapalliE Rand Sutherland
Jun 30, 2016·Antioxidants & Redox Signaling·Sashwati Roy
Aug 26, 2016·Immunological Reviews·Mallary C Greenlee-Wacker
Oct 28, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·MacRae F LintonPatricia G Yancey
Dec 23, 2016·Cell Death & Disease·Charles YinBryan Heit
Dec 21, 2016·Journal of Biomedical Materials Research. Part a·Hongxuan QuanHyeong-Cheol Yang
Feb 9, 2017·Apoptosis : an International Journal on Programmed Cell Death·Pascal DjiadeuNades Palaniyar
Mar 21, 2018·International Journal of Molecular Sciences·Xavier PalomerManuel Vázquez-Carrera
Oct 27, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroki KimuraMasaharu Nishimura
Dec 23, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew E LongAnne M Manicone
Jan 6, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chunling JiangGuochang Hu
Dec 7, 2017·Frontiers in Immunology·Lívia C BarrosoMauro Martins Teixeira
Oct 4, 2014·Journal of Cell Death·Jenna M McCracken, Lee-Ann H Allen
Feb 25, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Megan N MichalskiLaurie K McCauley
Mar 5, 2016·Diabetologia·Lily Boutens, Rinke Stienstra

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