Modulation of Macrophage Phenotype by Biodegradable Polyurethane Nanoparticles: Possible Relation between Macrophage Polarization and Immune Response of Nanoparticles

ACS Applied Materials & Interfaces
Yen-Jang HuangShan-hui Hsu

Abstract

Nanomaterials with surface functionalized by different chemical groups can either provoke or attenuate the immune responses of the nanomaterials, which is critical to their biomedical efficacies. In this study, we demonstrate that synthetic waterborne polyurethane nanoparticles (PU NPs) can inhibit the macrophage polarization toward the M1 phenotype but not M2 phenotype. The surface-functionalized PU NPs decrease the secretion levels of proinflammatory cytokines (TNF-α and IL-1β) for M1 macrophages. Specifically, PU NPs with carboxyl groups on the surface exhibit a greater extent of inhibition on M1 polarization than those with amine groups. These water-suspended PU NPs reduce the nuclear factor-κB (NF-κB) activation and suppress the subsequent NLR family pyrin domain containing 3 (NLRP3) inflammasome signals. Furthermore, the dried PU films assembled from PU NPs have a similar effect on macrophage polarization and present a smaller shifting foreign body reaction (FBR) in vivo than the conventional poly(l-lactic acid). Taken together, the biodegradable waterborne PU NPs demonstrate surface-dependent immunosuppressive properties and macrophage polarization effects. The findings suggest potential therapeutic applications of PU NP...Continue Reading

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Citations

Apr 4, 2019·International Journal of Molecular Sciences·Shih-Heng ChenFeng-Huei Lin
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Abel Po-Hao HuangShan-Hui Hsu
Mar 25, 2021·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Hazel LinAlberto Bianco
Jun 18, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Min HeWeidong Tian
Aug 7, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Congcong LinLiang Ouyang
Aug 14, 2019·Bioconjugate Chemistry·Yanyan HuaiPriyabrata Mukherjee
Jan 20, 2021·ACS Biomaterials Science & Engineering·Tsung-Han LeeShan-Hui Hsu
Sep 7, 2019·Chemical Reviews·Mohammad Javad HajipourMorteza Mahmoudi
Aug 14, 2019·ACS Applied Materials & Interfaces·Cheng-Tien Hsieh, Shan-Hui Hsu
Sep 21, 2021·ACS Applied Materials & Interfaces·Dipika NandiAshish Kulkarni
Oct 30, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Wali MuhammadChangyou Gao

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