PMID: 9437734Jan 23, 1998Paper

Modulation of memory, reinforcement and anxiety parameters by intra-amygdala injection of cholecystokinin-fragments Boc-CCK-4 and CCK-8s

Peptides
J P HustonR U Hasenöhrl

Abstract

This series of experiments examined the effects of the cholecystokinin (CCK) fragments Boc-CCK-4 and CCK-8s on memory, reinforcement and anxiety following unilateral injection into the central nucleus of the amygdala (CeA). In experiment 1, rats with chronically implanted cannulae were injected with CCK-8s or Boc-CCK-4 and were tested on a one-trial uphill avoidance task. Post-trial injection of 20 ng Boc-CCK-4 or 1 ng CCK-8s was found to improve the retention performance, whereas lower and higher doses had no effect. The hypermnestic effects of Boc-CCK-4 and CCK-8s were no longer evident when injection was performed 5 h, rather than immediately, after the learning trial. In experiment 2, the elevated plus-maze was used to gauge anxiogenous properties of intra-amygdala injections of Boc-CCK-4 and CCK-8s in memory-enhancing doses. The treatment with 20 ng Boc-CCK-4 and 1 ng CCK-8s did not influence the number of entries into and time spent on the open and enclosed arms of the maze as well as other anxiety-related behaviors. In experiment 3, possible reinforcing effects of the CCK-fragments were examined. After intra-amygdala injection of Boc-CCK-4 or CCK-8s in memory-enhancing doses the rats were placed into one of four restrict...Continue Reading

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Citations

Dec 13, 2003·Neurobiology of Learning and Memory·F A M de SouzaA M de Oliveira
Oct 18, 2000·Regulatory Peptides·J F Rehfeld
May 15, 2012·Pharmacological Reports : PR·Akbar Hajizadeh MoghaddamAli Roohbakhsh
Sep 13, 2006·Journal of Peptide Science : an Official Publication of the European Peptide Society·Andreas AxénMathias Hallberg
Sep 3, 2011·Journal of Neurochemistry·Christian P MüllerMaria A De Souza Silva
Jun 1, 2005·Biological Psychology·Ronald SchneiderReinhard Pietrowsky
Sep 3, 2013·Behavioural Brain Research·Shengchang YangBin Cong
Jun 20, 2002·Neurobiology of Learning and Memory·Bettina BertMechthild Voits
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Mar 28, 2017·Reviews in the Neurosciences·Santiago Ballaz
Jun 22, 2021·The Journal of Physiology·Orla R M WoodwardJo E Lewis

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