PMID: 2484579Jul 1, 1989Paper

Modulation of metal toxicity by metallothionein

Biological Trace Element Research
Gunnar Nordberg

Abstract

Toxic properties of several metals may be modified, since they are bound to metallothionein in vivo. Such modulation is particularly well known for cadmium (Cd), whose acute effects are prevented by metallothionein induction, whereas chronic effects on the kidney are partly explained on the basis of transport of cadmium-metallothionein (CdMt) into the kidney. Although intracellular Mt synthesis is induced by Cd, offering partial protection, nephrotoxicity may occur at times when such protection is insufficient. Perturbations in renal calcium metabolism may be an important basis for membrane dysfunction leading to proteinuria.

References

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Dec 1, 1975·Environmental Health Perspectives·M Nordberg, G F Nordberg
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Nov 5, 2010·Cognition·Karin S PilzIan M Thornton

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Citations

Dec 22, 1995·Chemico-biological Interactions·B Quintanilla-VegaB A Fowler
Jan 1, 1994·Occupational and Environmental Medicine·A S RowlandA J Wilcox
Aug 1, 1994·European Journal of Pediatrics·G DraschG Roider
Apr 8, 2000·Critical Reviews in Biochemistry and Molecular Biology·A T MilesV Rodilla
Aug 10, 2007·Kidney International·W C ProzialeckJ V Bonventre
Mar 1, 1994·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·A NagyovaE Ginter
Feb 22, 2014·Journal of Molecular Evolution·Nina SerénYlenia Chiari
Nov 17, 1998·Chemico-biological Interactions·D R SmithB A Fowler
Aug 21, 2007·Environmental Research·Alfred Bogomir KobalJosko Osredkar
Sep 18, 2012·Environmental Toxicology and Pharmacology·Kanyarat BoonprasertKesara Na-Bangchang
Feb 1, 1991·Acta Physiologica Scandinavica·M Pérez de la MoraK Fuxe
Apr 10, 2020·Environmental Science and Pollution Research International·Pauline CourtoisFranck Vandenbulcke
May 4, 2005·Cancer Research·Darren MagdaJoseph G Hacia

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