Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease.

International Journal of Molecular Sciences
Alex Cleber Improta-CariaBruno Solano de Freitas Souza

Abstract

Alzheimer disease (AD) is one of the most common neurodegenerative diseases, affecting middle-aged and elderly individuals worldwide. AD pathophysiology involves the accumulation of beta-amyloid plaques and neurofibrillary tangles in the brain, along with chronic neuroinflammation and neurodegeneration. Physical exercise (PE) is a beneficial non-pharmacological strategy and has been described as an ally to combat cognitive decline in individuals with AD. However, the molecular mechanisms that govern the beneficial adaptations induced by PE in AD are not fully elucidated. MicroRNAs are small non-coding RNAs involved in the post-transcriptional regulation of gene expression, inhibiting or degrading their target mRNAs. MicroRNAs are involved in physiological processes that govern normal brain function and deregulated microRNA profiles are associated with the development and progression of AD. It is also known that PE changes microRNA expression profile in the circulation and in target tissues and organs. Thus, this review aimed to identify the role of deregulated microRNAs in the pathophysiology of AD and explore the possible role of the modulation of microRNAs as a molecular mechanism involved in the beneficial actions of PE in AD.

References

Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E H KooD L Price
Aug 1, 1988·Genomics·R E TanziJ F Gusella
May 16, 1984·Biochemical and Biophysical Research Communications·G G Glenner, C W Wong
Dec 17, 1998·Trends in Cell Biology·E M Mandelkow, E Mandelkow
Apr 27, 2001·Medicine and Science in Sports and Exercise·A J SchuitD Kromhout
May 6, 2003·The Journal of Biological Chemistry·Dongsheng CaiSteven E Shoelson
Nov 19, 2003·Molecular and Cellular Biochemistry·Alok K BanerjeeSajal Chakraborti
Dec 19, 2003·Genes & Development·Rui YiBryan R Cullen
Jul 31, 2004·Science·Ji-Joon SongLeemor Joshua-Tor
Sep 10, 2004·Nucleic Acids Research·Yan Zeng, Bryan R Cullen
Sep 17, 2004·The EMBO Journal·Yoontae LeeV Narry Kim
Nov 9, 2004·Nature·Richard I GregoryRamin Shiekhattar
Nov 9, 2004·Nature·Ahmet M DenliGregory J Hannon
Mar 1, 2005·Trends in Endocrinology and Metabolism : TEM·Leona PlumJens C Brüning
Jun 17, 2006·Journal of Applied Physiology·Arthur F KramerStanley J Colcombe
May 17, 2007·IUBMB Life·Sergio T FerreiraFernanda G De Felice
Feb 9, 2008·Neurobiology of Disease·A ParachikovaC W Cotman
Apr 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sébastien S HébertBart De Strooper
Jun 13, 2008·Nature·Brandi N DavisAkiko Hata
Aug 1, 2008·Nature·Daehyun BaekDavid P Bartel
Aug 8, 2008·Molecular Neurodegeneration·Neha PatelAleister J Saunders
Nov 7, 2008·The Journal of Biological Chemistry·Vincent BoissonneaultPatrick Provost
Dec 27, 2008·Neurobiology of Disease·Sébastien S HébertBart De Strooper
Jan 24, 2009·Nature Reviews. Molecular Cell Biology·V Narry KimMikiko C Siomi
Jun 26, 2009·British Journal of Sports Medicine·Alejandro Lucia, Jonatan R Ruiz
Oct 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert VassarPhilip C Wong
Jan 1, 2007·Gene Regulation and Systems Biology·Hyman M SchipperEugenia Wang
Dec 8, 2009·Science·Chimari OkadaTomitake Tsukihara
Jan 12, 2010·Journal of Alzheimer's Disease : JAD·M Paul Murphy, Harry LeVine
Jan 30, 2010·Journal of Applied Physiology·Shlomit Radom-AizikDan M Cooper

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Citations

Oct 13, 2020·Journal of Alzheimer's Disease : JAD·Melanie HüttenrauchSusana Castro-Obregón
Jun 10, 2021·Nature Reviews. Drug Discovery·Carolina Gubert, Anthony J Hannan
Jun 3, 2021·International Journal of Molecular Sciences·Julian ZacharjaszKamilla Bąkowska-Żywicka
Jun 1, 2021·Epilepsy & Behavior : E&B·Bruno Raphael Ribeiro CavalcanteRicardo Augusto Leoni De Sousa
Jun 22, 2021·Journal of Molecular Neuroscience : MN·Inna Shvarts-SerebroBoaz Barak
Jul 15, 2021·Revista da Associação Médica Brasileira·Alex Cleber Improta-CariaTheolis Costa Barbosa Bessa

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Methods Mentioned

BETA
transgenic

Software Mentioned

miRPath
DIANA

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