Modulation of microvascular function following low-dose exposure to the organophosphorous compound malathion in human skin in vivo

Journal of Applied Physiology
P Boutsiouki, Geraldine F Clough

Abstract

This study investigates whether malathion, a widely used organophosphate insecticide, has its effects on cutaneous vasculature in healthy human volunteers through its anticholinergic activity or through the modulation of other, noncholinergic pathways. Acute, low-dose exposure to malathion (10 mg/ml for 5 h under occlusive dressing) caused a significant increase in cutaneous blood flux, monitored by using laser-Doppler flowmetry and imaging. It had little effect on tissue levels of ACh, nitric oxide, and histamine assayed in dermal dialysate collected from malathion-exposed and control-treated skin. The duration of the cutaneous vascular response to exogenous ACh (2%) delivered by iontophoresis was significantly enhanced by preexposure to malathion, both <1 h after its removal and 24 h later (P < 0.001). At <1 h, the time to 50% decay of the response was 24 +/- 4 and 50 +/- 8 min in control and malathion-treated skin, respectively. Malathion also enhanced the size and duration of the axon reflex-mediated vasoresponse to ACh. The increase in blood flux to malathion and the endothelium-mediated response to exogenous ACh, both in the presence and absence of malathion, were attenuated by pretreatment of the skin with atropine and l...Continue Reading

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Citations

Mar 26, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M DuschRoman Rukwied
Jun 15, 2011·Physiology·Jaume PadillaM Harold Laughlin
May 7, 2010·Journal of Biomedicine & Biotechnology·Shouhong ZhouGengrong Chen
Jan 1, 2008·Toxicology Mechanisms and Methods·Janet R WetherellGeraldine F Clough
Jul 4, 2012·Burns : Journal of the International Society for Burn Injuries·Anders SamuelssonFolke Sjöberg
Dec 21, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Simon FarneboFolke Sjöberg
Aug 1, 2006·Trends in Pharmacological Sciences·Jean-Luc CracowskiJohn R Halliwill
Nov 8, 2016·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Kenneth T Bogen, Ankur Singhal

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