Modulation of mitochondrial functions by xenobiotic-induced microRNA: From environmental sentinel organisms to mammals

The Science of the Total Environment
Mario Alberto Burgos-AcevesLillà Lionetti

Abstract

Mitochondria play a crucial role in energetic metabolism, signaling pathways, and overall cell viability. They are in the first line in facing cellular energy requirements in stress conditions, such as in response to xenobiotic exposure. Recently, a novel regulatory key role of microRNAs (miRNAs) in important signaling pathways in mitochondria has been proposed. Consequently, alteration in miRNAs expression by xenobiotics could outcome into mitochondrial dysfunction, reactive oxygen species overexpression, and liberation of apoptosis or necrosis activating proteins. The aim of this review is to show the highlights about mitochondria-associated miRNAs in cellular processes exposed to xenobiotic stress in different cell types involved in detoxification processes or sensitive to environmental hazards in marine sentinel organisms and mammals.

Citations

Jan 23, 2019·Environmental Science and Pollution Research International·Laura ButrimavičienėJanina Baršienė
Jan 20, 2019·Molecular Reproduction and Development·Donatella Carbone, Caterina Faggio
Dec 13, 2019·Journal of Applied Toxicology : JAT·Xiaoru ChangMeng Tang
Feb 2, 2020·Environmental Science and Pollution Research International·Mohamed M Abdel-DaimSaad Alkahtani
Nov 23, 2019·Environmental Science and Pollution Research International·Nikola HodkovicovaZdenka Svobodova
Jan 29, 2019·Frontiers in Physiology·Ilaria Di GregorioLillà Lionetti
Feb 9, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Ritwick BhattacharyaNimai Chandra Saha
Jan 29, 2021·Ecotoxicology and Environmental Safety·Deliang YuXiao Peng
May 20, 2020·Toxicology Reports·Satheeswaran BalasubramanianEkambaram Perumal
May 19, 2020·The Science of the Total Environment·Oriol Rodríguez-RomeuAnna Soler-Membrives
Apr 4, 2021·Environmental Toxicology and Pharmacology·Ahmad Mohamadi YalsuyiCaterina Faggio

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