Modulation of mitogen-activated protein kinases (MAPK) activity in response to different immune stimuli in haemocytes of the common periwinkle Littorina littorea

Fish & Shellfish Immunology
Nadya V IakovlevaKenneth B Storey

Abstract

The modulation of mitogen-activated protein kinase (MAPK) activity in haemocytes of the common periwinkle (Littorina littorea) in response to immune challenges by lipopolysaccharide from Echerichia coli (LPS), mannan from baker's yeast Saccharomyces cerevisiae and secretory-excretory products (SEP) of trematodes Himasthla elongata (Echinostomatidae) or after the treatment with phorbol ester (PMA) has been studied by Western blotting using affinity purified rabbit polyclonal antibodies. Exposure of the cells in suspension to PMA, LPS and mannan triggered an activation of p38 and ERK2. The JNK-mediated cascade was modulated differently by the elicitors examined. PMA treatment caused a transient activation of the JNK54 isoform, LPS exposure resulted in a decrease in activity of JNK46, and mannan had no effect on JNK phosphorylation status. Incubation of periwinkle haemocytes in culture medium containing trematode SEP did not affect the activity of any MAPK.

References

Feb 22, 2003·Experimental Parasitology·Alexander M Gorbushin, Tatjana G Shaposhnikova
Jul 10, 2004·General and Comparative Endocrinology·Laura CanesiGabriella Gallo
Dec 22, 2004·Cell Cycle·Concetta BubiciGuido Franzoso
Feb 22, 2005·International Journal for Parasitology·Louise D PlowsAnthony J Walker
Mar 31, 2005·Archives of Biochemistry and Biophysics·Vadim V Sumbayev, Inna M Yasinska

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Citations

Dec 3, 2014·Developmental and Comparative Immunology·Alexander M Gorbushin, Elena A Borisova
Nov 26, 2015·Developmental and Comparative Immunology·E A PilaP C Hanington
Apr 5, 2008·Fish & Shellfish Immunology·Alexander M Gorbushin, Nadya V Iakovleva
Nov 29, 2020·Journal of Neuroinflammation·Qiushi FengXiaosheng Wang
Aug 14, 2018·Fish & Shellfish Immunology·Jing Liu, Yong Zhao
Jul 17, 2021·Developmental and Comparative Immunology·Guosheng LiuMingliang Chen
Sep 3, 2021·Computational and Structural Biotechnology Journal·Qian LiuXiaosheng Wang

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