PMID: 11314680Apr 21, 2001Paper

Modulation of MK-801-induced behaviour by noradrenergic agents in mice

Psychopharmacology
A HarkinB E Leonard

Abstract

Inhibition of glutamatergic N-methyl-D-aspartate (NMDA) receptors following the administration of NMDA receptor antagonists results in psychotic-like behaviour. Whereas it is known that pharmacological manipulation of dopaminergic and serotonergic pathways affect this drug-induced psychosis, a role for noradrenaline has not yet been clearly defined. Thus, in the present study, we assessed a possible role for noradrenaline in the behavioural response to the non-competitive NMDA receptor anatgonist, MK-801, in male CD-I mice. MK-801 (0.02-1.28 mg/kg; ED50 0.2 mg/kg; s.c.) induced a dose-dependent increase in locomotor, stereotypic and ataxic behaviours. Pre-treatment with the noradrenaline re-uptake inhibitors, desipramine (10 mg/kg; i.p.) and reboxetine (20 mg/kg; i.p.), attenuated the locomotor, stereotypic and ataxic response to MK-801 (0.2 mg/kg; s.c.). The noradrenergic system was lesioned with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP-4, 50 mg/kg; i.p., 7 and 4 days prior to challenge) to reduce noradrenaline concentrations in the cortex by 70%-80%. Whereas DSP-4 lesioning had little effect on the response to MK-801, it completely reversed the attenuating effects of reboxetine. Pre-treatment with the a...Continue Reading

Citations

Aug 4, 2004·Psychopharmacology·Jinhua WuLei Yu
Jun 16, 2004·Behavioural Brain Research·Kenichi MishimaMichihiro Fujiwara
Dec 5, 2003·Neuropharmacology·Sanjeev K BhardwajLalit K Srivastava
May 22, 2003·Pharmacology, Biochemistry, and Behavior·Michelle D Jones, Ellen J Hess
Feb 17, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·William MarrsJ David Jentsch
Jan 16, 2008·Behavioural Pharmacology·Mikhail KalinichevDeclan N C Jones
Sep 13, 2014·Current Behavioral Neuroscience Reports·Alexandra D ForrestSteven J Siegel
Nov 11, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Do-Hoon KimDong-Keun Song
May 28, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Andrew HarkinJohn P Kelly
Feb 25, 2009·The International Journal of Neuropsychopharmacology·Laura GrayAnthony J Hannan
Feb 6, 2008·The International Journal of Neuropsychopharmacology·María Cecilia ScorzaFrancesc Artigas
Dec 23, 2004·Journal of Periodontal Research·Torbjørn BreivikFrode Fonnum
Jul 18, 2017·Neuroscience and Biobehavioral Reviews·Mehdi GhasemiAhmad Salehi

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