PMID: 9536461Apr 16, 1998Paper

Modulation of monoamine oxidase activity in different brain regions and platelets following exposure of rats to methylmercury

Neurotoxicology and Teratology
S K ChakrabartiJ C Panisset

Abstract

Monoamine oxidase (MAO; EC 1.4.3.4) is known to have an important role in the regulation of biogenic amines in the brain and peripheral tissues. It is also known that circulating platelets represent an excellent model for an easy assessment of the effect of MAO-B inhibitors in extracerebral tissue. The present study was carried out to determine the effects of methylmercury (MeHg) on the activity of MAO in synaptosomes of different brain regions of male Sprague-Dawley rats as well as in rat blood platelets both in vitro and in vivo. MeHg pretreatment inhibited the activity of MAO in the synaptosomes of the cortex, hypothalamus, hippocampus, striatum, cerebellum, and brain stem in a concentration-dependent (0-10 microM) manner. The threshold concentration of MeHg for such inhibition in different brain synaptosomes was found to be the same (i.e., 1 microM) except for in the rat striatum it was 2.5 microM, and the IC50 value for MeHg was found to be around 2.1 microM. Significant inhibition of the MAO activity was also observed in synaptosomes of the cortex, cerebellum, hypothalamus, and hippocampus as well as in platelets of rats 24 h after treatment by gavage with a total cumulative dose of 35 mg/kg (5 mg/kg/day for 7 days). The ...Continue Reading

References

Dec 1, 1977·Environmental Research·L W Chang
May 1, 1977·Biochemical Pharmacology·C H Donnelly, D L Murphy
Oct 10, 1975·Life Sciences·D J Edwards, S S Chang
Jul 1, 1989·Biological Trace Element Research·K PeterssonM Vahter
Feb 15, 1988·Experientia·M B Youdim
Feb 1, 1986·Journal of the Neurological Sciences·V W Yong, T L Perry
Jan 1, 1972·Annual Review of Pharmacology·T W Clarkson
Aug 1, 1972·Food and Cosmetics Toxicology·S Skerfving
Jul 20, 1973·Science·F BakirR A Doherty
Jul 26, 1974·Nature·M SandlerE Hanington
Nov 1, 1965·Biochemical Pharmacology·M Krajl
Dec 1, 1980·The Journal of Pharmacy and Pharmacology·D ParkinsonB A Callingham
May 1, 1980·Biochemical Pharmacology·C Mitra, S R Guha
Jul 1, 1980·Journal of Neurochemistry·H KinemuchiK Kamijo
Feb 1, 1982·Psychiatry Research·E GillerL Harkness
Mar 1, 1982·Journal of Neurochemistry·C J Fowler, K F Tipton
Nov 9, 1981·Life Sciences·C T Giambalvo, R E Becker
Apr 1, 1980·Toxicology and Applied Pharmacology·R Von BurgA Shamoo
Jul 1, 1980·Toxicology and Applied Pharmacology·A NaganumaN Imura

❮ Previous
Next ❯

Citations

Jul 13, 2005·Journal of Toxicology and Environmental Health. Part a·Christopher J StamlerHing Man Chan
Dec 5, 2013·Chemico-biological Interactions·Nadia Z ShabanOmayma M Sadek
Mar 9, 2013·Journal of Bioenergetics and Biomembranes·Roberta de Paula MartinsAlexandra Latini
Jul 12, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Kun HaoHao-Ye Li
Aug 13, 2010·Aquatic Toxicology·Karin BergAnders Goksøyr
Oct 28, 2009·Pharmacology, Biochemistry, and Behavior·Ying XuWilliam O Ogle
Jul 26, 2008·Neurotoxicology·M Christopher NewlandMiranda N Reed
Aug 10, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Rosilene Rodrigues KaizerMaria Rosa Chitolina Schetinger
Jun 10, 2015·Toxicology Mechanisms and Methods·Yueting Shao, Hing Man Chan
Jul 16, 2009·Neurotoxicology and Teratology·Niladri Basu, Jessica Head
Feb 24, 2006·Neurotoxicology and Teratology·Peter BeyroutyHing Man Chan
Sep 12, 2009·Neurotoxicology and Teratology·Nadia AbdelouahabLarissa Takser
Jul 1, 2005·European Journal of Pharmacology·Ying XuXue-Jun Li
Apr 5, 2007·Neurochemical Research·V C BorgesC W Nogueira
Jun 2, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ehsan H Abu-ZeidShereen El Abdel-Hamid
Jun 15, 2005·Environmental Science & Technology·Niladri BasuHing Man Chan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.