Modulation of motor excitability by cortical optogenetic theta burst stimulation

PloS One
Chun-Wei WuJia-Jin Jason Chen

Abstract

Intermittent theta burst stimulation (iTBS) and continuous theta burst stimulation (cTBS) are protocols used in repetitive transcranial magnetic stimulation (rTMS) or cortical electrical stimulation (CES) to facilitate or suppress corticospinal excitability. However, rTMS and CES excite all types of neuron in the target cortex probed by the coil or electrode, making it difficult to differentiate the effect of TBS on specific neural circuits involved in motor plasticity. In this study, TBS protocols were converted into an optogenetic model to achieve focalized and cell-type-specific cortical modulation. Light-sensitive channelrhodopsin-2 (ChR2) was expressed in the glutamatergic neuron in the primary motor cortex (M1) driven by the CaMKIIα promoter. A custom-made optrode comprising an optical fiber and a metal cannula electrode was fabricated to achieve optogenetic stimulation and simultaneous local field potential (LFP) recording. Single-pulse CES was delivered into M1 to elicit motor-evoked potential (MEP), which served as an indicator of motor excitability, before and after TBS intervention. Results show that both CES-iTBS and optogenetic iTBS (Opto-iTBS) can potentiate MEP activity. However, CES-cTBS suppressed MEP activity ...Continue Reading

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Citations

Jun 1, 2021·Frontiers in Neuroscience·Windsor Kwan-Chun TingChristian Ethier
Dec 23, 2021·Proceedings of the National Academy of Sciences of the United States of America·Alzahraa AmerJohn H Martin

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Methods Mentioned

BETA
fluorescence microscopy
light scattering

Software Mentioned

GraphPad
GraphPad Prism

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