Abstract
Intermittent theta burst stimulation (iTBS) and continuous theta burst stimulation (cTBS) are protocols used in repetitive transcranial magnetic stimulation (rTMS) or cortical electrical stimulation (CES) to facilitate or suppress corticospinal excitability. However, rTMS and CES excite all types of neuron in the target cortex probed by the coil or electrode, making it difficult to differentiate the effect of TBS on specific neural circuits involved in motor plasticity. In this study, TBS protocols were converted into an optogenetic model to achieve focalized and cell-type-specific cortical modulation. Light-sensitive channelrhodopsin-2 (ChR2) was expressed in the glutamatergic neuron in the primary motor cortex (M1) driven by the CaMKIIα promoter. A custom-made optrode comprising an optical fiber and a metal cannula electrode was fabricated to achieve optogenetic stimulation and simultaneous local field potential (LFP) recording. Single-pulse CES was delivered into M1 to elicit motor-evoked potential (MEP), which served as an indicator of motor excitability, before and after TBS intervention. Results show that both CES-iTBS and optogenetic iTBS (Opto-iTBS) can potentiate MEP activity. However, CES-cTBS suppressed MEP activity ...Continue Reading
References
Mar 19, 1986·Brain Research·J LarsonG Lynch
Apr 1, 1996·The European Journal of Neuroscience·G Hess, J P Donoghue
Jan 25, 2005·Neuron·Ying-Zu HuangJohn C Rothwell
Aug 24, 2005·Nature Neuroscience·Edward S BoydenKarl Deisseroth
Apr 6, 2007·Nature·Feng ZhangKarl Deisseroth
Sep 18, 2007·Journal of Neural Engineering·Alexander M AravanisKarl Deisseroth
Dec 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Viviana GradinaruKarl Deisseroth
Mar 17, 2009·Brain Topography·Lizbeth Cárdenas-MoralesCarlos Schönfeldt-Lecuona
May 19, 2009·Behavioural Brain Research·Erich Talamoni FonoffManoel Jacobsen Teixeira
Mar 6, 2010·Nature Protocols·Feng ZhangKarl Deisseroth
Jul 17, 2010·Brain Stimulation·Janna Marie HoogendamVincenzo Di Lazzaro
Oct 11, 2011·Nature Methods·Shengli ZhaoGuoping Feng
Jun 5, 2012·Cerebral Cortex·Masashi HamadaJohn C Rothwell
Jun 13, 2012·Neuropharmacology·Robert SchulzFriedhelm C Hummel
Aug 14, 2012·Journal of Neuroscience Methods·Wenhui Xiong, Xiaoming Jin
Mar 29, 2013·Cerebral Cortex·Iris WiegandKathrin Finke
Aug 2, 2013·Cerebral Cortex·Julia T MattsonMichael D Rugg
Oct 29, 2013·Acta Pharmacologica Sinica·Yu-feng XieJohn F Macdonald
Aug 31, 2014·The Journal of Physiology·Vincenzo Di Lazzaro, John C Rothwell
Dec 3, 2014·Brain Research·John Larson, Erin Munkácsy
Jan 23, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sonja Seeger-ArmbrusterLouise C Parr-Brownlie
May 28, 2015·Brain Stimulation·Miles Wischnewski, Dennis J L G Schutter
Mar 8, 2016·Brain Stimulation·A SuppaJ C Rothwell
Aug 24, 2017·Molecular Psychiatry·X HuangT-F Yuan
Citations
Jan 18, 2020·Neural Plasticity·Hui-Hua LiuTsung-Hsun Hsieh
Jun 1, 2021·Frontiers in Neuroscience·Windsor Kwan-Chun TingChristian Ethier
Sep 4, 2021·Journal of Neural Engineering·Shun-Min Samuel WangChih-Wei Peng
Dec 23, 2021·Proceedings of the National Academy of Sciences of the United States of America·Alzahraa AmerJohn H Martin