Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise

Journal of the National Cancer Institute
Allison S BetofMark W Dewhirst

Abstract

Exercise has been shown to improve postischemia perfusion of normal tissues; we investigated whether these effects extend to solid tumors. Estrogen receptor-negative (ER-, 4T1) and ER+ (E0771) tumor cells were implanted orthotopically into syngeneic mice (BALB/c, N = 11-12 per group) randomly assigned to exercise or sedentary control. Tumor growth, perfusion, hypoxia, and components of the angiogenic and apoptotic cascades were assessed by MRI, immunohistochemistry, western blotting, and quantitative polymerase chain reaction and analyzed with one-way and repeated measures analysis of variance and linear regression. All statistical tests were two-sided. Exercise statistically significantly reduced tumor growth and was associated with a 1.4-fold increase in apoptosis (sedentary vs exercise: 1544 cells/mm(2), 95% CI = 1223 to 1865 vs 2168 cells/mm(2), 95% CI = 1620 to 2717; P = .048), increased microvessel density (P = .004), vessel maturity (P = .006) and perfusion, and reduced intratumoral hypoxia (P = .012), compared with sedentary controls. We also tested whether exercise could improve chemotherapy (cyclophosphamide) efficacy. Exercise plus chemotherapy prolonged growth delay compared with chemotherapy alone (P < .001) in the...Continue Reading

References

Nov 1, 1995·British Journal of Cancer·D M BrizelC A Piantadosi
Feb 15, 1993·International Journal of Radiation Oncology, Biology, Physics·T W SecombJ F Gross
Mar 21, 2002·Nature Reviews. Cancer·Adrian L Harris
Jun 6, 2003·Nature·Donald P Bottaro, Lance A Liotta
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
May 26, 2005·JAMA : the Journal of the American Medical Association·Michelle D HolmesGraham A Colditz
Sep 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lee W JonesJohn R Mackey
Oct 17, 2006·Molecular Cancer Therapeutics·Beverly A Teicher
Dec 15, 2006·The New England Journal of Medicine·Alan SandlerDavid H Johnson
Dec 28, 2007·The New England Journal of Medicine·Kathy MillerNancy E Davidson
Apr 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard B SaltzJim Cassidy
May 27, 2008·Nature Reviews. Cancer·Mark W DewhirstBenjamin Moeller
Aug 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Melinda L IrwinLeslie Bernstein
Feb 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin ReckChristian Manegold
Dec 5, 2009·Journal of Applied Physiology·Lee W JonesMark W Dewhirst
Dec 29, 2009·Frontiers in Bioscience (Landmark Edition)·Katie DeClerck, Randolph C Elble
Jun 2, 2011·Nature Reviews. Drug Discovery·Peter Carmeliet, Rakesh K Jain
Jul 12, 2011·Physiological Reviews·Shom GoelRakesh K Jain
Nov 25, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Lee W JonesAmy P Abernethy
May 19, 2012·Journal of Applied Physiology·Lee W JonesStephen J Freedland
May 23, 2012·Brain, Behavior, and Immunity·Allison S BetofLee W Jones
Sep 27, 2012·Journal of Mammary Gland Biology and Neoplasia·Robert S Kerbel
Mar 15, 2014·Journal of the National Cancer Institute·Lee W Jones, Mark W Dewhirst
Mar 15, 2014·Journal of the National Cancer Institute·Danielle J McCulloughBradley J Behnke
Mar 19, 2014·Medicine and Science in Sports and Exercise·Kerry S CourneyaJohn R Mackey

❮ Previous
Next ❯

Citations

Feb 7, 2016·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Mark W DewhirstKathleen A Ashcraft
Oct 29, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L LoughneyS Jack
Jun 16, 2015·Pharmacology & Therapeutics·Dietmar W Siemann, Michael R Horsman
Sep 25, 2015·Pathobiology of Aging & Age Related Diseases·Xuang GeWarren C Ladiges
Jun 6, 2016·Trends in Molecular Medicine·Manja Idorn, Pernille Hojman
Nov 23, 2017·Exercise and Sport Sciences Reviews·Jennifer M WigginsBradley J Behnke
Jan 27, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert U NewtonDaniel A Galvão
Jan 24, 2018·Journal of Applied Physiology·Linda A Buss, Gabi U Dachs
Nov 11, 2017·Nature Reviews. Cancer·Mark W Dewhirst, Timothy W Secomb
Sep 20, 2018·American Journal of Hematology·Priyanka A PophaliCarrie A Thompson
Dec 12, 2018·The Cochrane Database of Systematic Reviews·Lisa A LoughneySandy Jack
Feb 12, 2019·Annual Review of Physiology·John D MartinRakesh K Jain
Jul 5, 2017·Biochemical Society Transactions·Pernille Hojman
May 20, 2018·Scientific Reports·L BerruetaH M Langevin
May 29, 2019·Pediatric Blood & Cancer·Miriam B G MorrellKeri L Schadler
Sep 26, 2017·Nature Reviews. Cancer·Graeme J KoelwynLee W Jones
Jun 18, 2019·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Jarlath C BolgerWilliam B Robb
Jun 19, 2019·The Journal of Physiology·Veridiana Mota MoreiraPaulo Cezar de Freitas Mathias
Jul 3, 2019·Current Oncology Reports·Allison Betof Warner, Jennifer L McQuade
Sep 19, 2019·Journal of the National Cancer Institute. Monographs·Lenat JoffeElena J Ladas
Oct 16, 2019·The Journal of Physiology·Gabriel Cardial TobiasVanessa Azevedo Voltarelli
May 23, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Vanessa J ThomasKate M Edwards
Feb 12, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Suzanne DufresneAmélie Rébillard
Jun 1, 2017·Current Opinion in Supportive and Palliative Care·Nicolas H HartRobert U Newton
Apr 16, 2019·Medicine and Science in Sports and Exercise·Camila S PadilhaRafael Deminice
Mar 11, 2020·Cells·Anderson VulczakLuciane Carla Alberici
Dec 20, 2017·Oncotarget·Oliver K GlassVictoria Seewaldt
Sep 29, 2019·Scientific Reports·Claudia Alvarez Florez BedoyaKeri L Schadler
Sep 21, 2016·International Anesthesiology Clinics·Lisa Loughney, Michael P W Grocott
Jun 14, 2020·Journal of Clinical Medicine·Venturini EGiallauria F
Apr 3, 2020·Journal of the National Cancer Institute·Rikki A CanniotoChristine B Ambrosone
Feb 14, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M PollánM Martín
Apr 30, 2020·Journal of the National Cancer Institute·Jennifer L GuidaKirsten K Ness
Feb 26, 2019·Frontiers in Oncology·Robert-Christopher Karl-Richard EschkePhilipp Zimmer
Jun 13, 2018·Nature Reviews. Cancer·Robert J GilliesRobert A Gatenby
Dec 5, 2019·Frontiers in Oncology·George Mattheolabakis, Constantinos M Mikelis

❮ Previous
Next ❯

Methods Mentioned

BETA
xenografts

Related Concepts

Related Feeds

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis