Modulation of nesfatin-1-induced cardiovascular effects by the central cholinergic system

Neuropeptides
Begum AydinMurat Yalcin

Abstract

Nesfatin-1, a peptide whose receptor is yet to be identified, has been shown to be involved in the modulation of feeding, stress, and metabolic responses. Recently, increasing evidence has supported a modulatory role of nesfatin-1 in cardiovascular activity. We have previously reported that nesfatin-1 causes an increase in blood pressure in normotensive and hypotensive rats by increasing plasma catecholamine, vasopressin, and renin levels. Recent reports suggest that nesfatin-1 may activate the central cholinergic system. However, there is no evidence showing an interaction between central nesfatin-1 and the cholinergic system. Therefore, this study aimed to determine whether the central cholinergic system may have a functional role in the nesfatin-1-induced cardiovascular effect observed in normotensive rats. Intracerebroventricular injection of nesfatin-1 caused short-term increases in mean arterial pressure and heart rate responses including bradycardic/tachycardic phases in normotensive animals. Central injection of nesfatin-1 increased the acetylcholine and choline levels in the posterior hypothalamus, as shown in microdialysis studies. Central pretreatment with the cholinergic muscarinic receptor antagonist atropine and/o...Continue Reading

Citations

Oct 12, 2018·Journal of the Endocrine Society·Martha A Schalla, Andreas Stengel
Mar 24, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Tommaso AngeloneTeresa Pasqua
Aug 1, 2021·General and Comparative Endocrinology·Krittika DotaniaUmesh Rai

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