Modulation of neuronal activity and plasma membrane properties with low-power millimeter waves in organotypic cortical slices

Journal of Neural Engineering
Victor PikovPeter H Siegel

Abstract

As millimeter waves (MMWs) are being increasingly used in communications and military applications, their potential effects on biological tissue has become an important issue for scientific inquiry. Specifically, several MMW effects on the whole-nerve activity were reported, but the underlying neuronal changes remain unexplored. This study used slices of cortical tissue to evaluate the MMW effects on individual pyramidal neurons under conditions mimicking their in vivo environment. The applied levels of MMW power are three orders of magnitude below the existing safe limit for human exposure of 1 mW cm(-2). Surprisingly, even at these low power levels, MMWs were able to produce considerable changes in neuronal firing rate and plasma membrane properties. At the power density approaching 1 microW cm(-2), 1 min of MMW exposure reduced the firing rate to one third of the pre-exposure level in four out of eight examined neurons. The width of the action potentials was narrowed by MMW exposure to 17% of the baseline value and the membrane input resistance decreased to 54% of the baseline value across all neurons. These effects were short lasting (2 min or less) and were accompanied by MMW-induced heating of the bath solution at 3 degre...Continue Reading

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Citations

Jul 14, 2011·Journal of Neural Engineering·Qing TangFan-Gang Zeng
Jun 30, 2011·Bioelectromagnetics·Maxim ZhadobovDaniel Thouroude
Jun 26, 2013·Biophysical Journal·Mikhail G ShapiroFrancisco Bezanilla
Sep 11, 2014·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Mary Redmayne, Olle Johansson
Aug 23, 2018·Journal of Neurophysiology·Corinne El KhoueiryNoëlle Lewis
Jul 21, 2010·Journal of Neural Engineering·Shy Shoham, Karl Deisseroth
Sep 22, 2019·International Journal of Environmental Research and Public Health·Myrtill Simkó, Mats-Olof Mattsson
Nov 14, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Igor Goychuk
Mar 18, 2021·Journal of Exposure Science & Environmental Epidemiology·Ken KaripidisAndrew Wood
Oct 30, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·M N Shneider, M Pekker
Oct 15, 2021·Biomedical Physics & Engineering Express·Hi Yuen SongChul Soon Park
May 18, 2017··Maria FiniWilliam J. Tyler

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