Modulation of neurotransmission in the guinea-pig vas deferens by capsaicin: involvement of calcitonin gene-related peptide and substance P.

British Journal of Pharmacology
J Ellis, G Burnstock

Abstract

1. The effects of capsaicin, calcitonin gene-related peptide and substance P were studied via three parameters in the guinea-pig vas deferens: the overflow of ATP and of tritiated noradrenaline, the mechanical responses to field stimulation and the mechanical responses to exogenous noradrenaline and alpha, beta-methylene ATP. 2. At 2 Hz, capsaicin inhibited the stimulus-evoked release of ATP, whereas it was without effect on the release of noradrenaline. At 20 Hz capsaicin did not affect the release of either of the cotransmitters. Capsaicin enhanced responses to alpha, beta-methylene ATP, but not to exogenous noradrenaline. 3. Calcitonin gene-related peptide, like capsaicin, inhibited the release of ATP, but not noradrenaline at 2 Hz and was without effect on release at 20 Hz. However, calcitonin gene related peptide inhibited responses to alpha, beta-methylene ATP and was without effect on responses to exogenous noradrenaline. 4. Substance P had no effect on the release of either noradrenaline or ATP at either frequency. However, like capsaicin it enhanced responses to alpha, beta-methylene ATP and was without effect on exogenous noradrenaline. 5. These results suggest that the actions of capsaicin on the guinea-pig isolated ...Continue Reading

References

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Citations

May 19, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Samera Iram, Charles H V Hoyle
Oct 9, 1990·European Journal of Pharmacology·K I MaynardG Burnstock
Sep 1, 1991·Trends in Pharmacological Sciences·I von Kügelgen, K Starke
Jan 1, 1990·Neurochemistry International·G Burnstock
Jun 1, 1991·Journal of Autonomic Pharmacology·C A Maggi
Apr 1, 1992·British Journal of Pharmacology·M E Drake, S A Petersen
Mar 1, 1996·British Journal of Pharmacology·A E Tomlinson, D R Poyner
Nov 26, 2013·Purinergic Signalling·Geoffrey Burnstock
Feb 25, 2014·Pharmacology & Therapeutics·Janette M Bulloch, Craig J Daly
Dec 14, 2004·Life Sciences·Luz CandenasJocelyn N Pennefather
Jan 16, 2010·Trends in Pharmacological Sciences·Geoffrey Burnstock, Alexej Verkhratsky
Nov 26, 1998·Japanese Journal of Pharmacology·M P Abbracchio, G Burnstock
Jan 7, 2017·Circulation Research·Geoffrey Burnstock
Jan 1, 1990·Annals of the New York Academy of Sciences·G Burnstock
Apr 1, 1993·The Journal of Urology·S C Kolbeck, W D Steers

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