Modulation of neutrophil superoxide response and intracellular diacylglyceride levels by the bacterial pigment pyocyanin.

Infection and Immunity
M Muller, T C Sorrell

Abstract

Low concentrations of pyocyanin are reported to enhance superoxide production by human neutrophils exposed to various stimuli, yet the mechanism remains unknown. Using lucigenin-enhanced chemiluminescence, we examined the kinetics of the neutrophil superoxide response in the presence of pyocyanin. At all concentrations (12.5 to 200 microM), pyocyanin decreased the peak superoxide response while prolonging the duration of the response. The prolonged response may be associated with an observed increase in intracellular diacylglyceride levels due to pyocyanin exposure.

References

Mar 1, 1991·Archives of Biochemistry and Biophysics·R TakahashiK Utsumi
Jan 1, 1991·Antibiotics and Chemotherapy·R U SorensenR L Waller
Jul 1, 1990·The Journal of Infectious Diseases·G J RasP J Cole
Feb 9, 1989·The New England Journal of Medicine·S J Weiss
Mar 1, 1987·Infection and Immunity·K M MillerR U Sorensen
Mar 12, 1987·Journal of Immunological Methods·H Gyllenhammar
Jun 1, 1987·The Journal of Clinical Investigation·A M CantinR G Crystal
Sep 1, 1986·European Journal of Biochemistry·D WatsonG W Taylor
Jan 1, 1987·Annual Review of Biochemistry·M J Berridge
Jun 1, 1981·Archives of Biochemistry and Biophysics·C C Winterbourn
Apr 1, 1984·The Biochemical Journal·B Halliwell, J M Gutteridge
Apr 30, 1984·Biochemical and Biophysical Research Communications·I FujitaS Minakami
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

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Citations

Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lynne R UsherMoira K B Whyte
Nov 4, 2008·Immunologic Research·Balázs Rada, Thomas L Leto
Jul 23, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yunxia Q O'MalleyBradley E Britigan
Mar 2, 2011·IUBMB Life·Jaime A RobledoFrancois Rouzaud
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Balázs RadaThomas L Leto

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