Modulation of nicotinamide adenine dinucleotide and poly(adenosine diphosphoribose) metabolism by calicheamicin gamma 1 in human HL-60 cells

Cancer Letters
B ZhaoA L Oronsky

Abstract

The mechanism of calicheamicin gamma 1-mediated cytotoxicity was studied in human promyelocytic HL-60 leukemic cells. Calicheamicin gamma 1 caused an increase in poly(ADP-ribose) polymerase activity in HL-60 cells parallel to cell death. This effect of the drug correlated with a decrease in intracellular NAD+ level. 3-Aminobenzamide, an inhibitor of poly(ADP-ribosylation), prevented the calicheamicin gamma 1-triggered cytotoxicity in a dose-dependent manner. Simultaneous with the reversal of cytotoxicity, the addition of 3-aminobenzamide to drug-treated cells also inhibited the increase in poly(ADP-ribosylation) and the reduction in cellular NAD+ content. These results indicate that poly(ADP-ribosylation) activation and the subsequent perturbations in NAD(+)-dependent metabolic reactions are associated with the cytotoxic properties of the antitumor antibiotic calicheamicin gamma 1.

References

Jun 1, 1979·The Journal of Clinical Investigation·N A BergerK K Kurohara
Feb 1, 1985·Carcinogenesis·G G PoirierP A Cerutti
Aug 15, 1985·The Biochemical Journal·J C Gaal, C K Pearson
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J E FlemingK G Bensch
Aug 15, 1988·Biochemical and Biophysical Research Communications·H WohlrabV Nemeth
Oct 15, 1988·Biochemical Pharmacology·C R Stubberfield, G M Cohen
Jun 14, 1988·Brain Research·G ColeT Saitoh
Dec 15, 1988·Biochemical and Biophysical Research Communications·Y DeguchiS Kishimoto
Jun 1, 1973·Analytical Biochemistry·C Bernofsky, M Swan
Feb 7, 1980·Nature·B W DurkaczS Shall
Feb 11, 1982·Biochemical and Biophysical Research Communications·L A ZwellingY Pommier

❮ Previous
Next ❯

Citations

Jan 1, 1996·International Archives of Occupational and Environmental Health·P C Dedon
May 28, 2013·International Journal of Hematology·Akihiro Takeshita
Jun 1, 1995·Bioorganic & Medicinal Chemistry·L YuP C Dedon
Aug 24, 1999·The Biochemical Journal·D D'AmoursG G Poirier
Jun 12, 2013·Frontiers in Bioscience (Landmark Edition)·Andrew J CowanRoland B Walter
May 24, 1996·Journal of Medicinal Chemistry·A L Smith, K C Nicolaou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.