Modulation of nicotine-induced attentional enhancement in rats by adrenoceptor antagonists

Psychopharmacology
Britta Hahn, I P Stolerman

Abstract

Understanding the neuropharmacological mechanisms mediating attentional enhancement by nicotine would help a targeted search for nicotinic compounds with retained therapeutic but reduced unwanted side-effects. Previous studies suggested that the dopamine-releasing effects of nicotine may not be of primary importance for its attention-enhancing properties. The present study examined the role of noradrenergic neurotransmission for the effects of nicotine on different response indices of an attentional paradigm. The effects of systemic injections of the alpha(1)-adrenoceptor antagonist prazosin that also displays significant affinity at alpha(2B) and alpha(2C)-adrenoceptors and the beta-adrenoceptor antagonist propranolol were tested in both the presence and absence of nicotine in rats trained in a version of the five-choice serial reaction time task. Nicotine generally enhanced the accuracy of signal detection, reduced omission errors and shortened response latencies. At the largest doses tested, both prazosin (1 mg/kg) and propranolol (10 mg/kg) impaired performance. For propranolol, these effects depended on the rate of target signal presentation. The two compounds differentially modulated the effects of nicotine. Propranolol (...Continue Reading

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Citations

Jul 17, 2013·Biochemical Pharmacology·Rogier B Poorthuis, Huibert D Mansvelder
Sep 17, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stan B Floresco, James D Jentsch
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Jun 19, 2012·Neuropharmacology·Britta HahnRobert W Buchanan
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May 12, 2006·Huan jing ke xue= Huanjing kexue·Gang XiaoKe-fa Cen
Sep 12, 2017·Current Protocols in Pharmacology·Guy A Higgins, Leo B Silenieks
May 15, 2020·Cognitive, Affective & Behavioral Neuroscience·Britta HahnAshleigh K Wells
Mar 3, 2021·Psychopharmacology·Chloe S ChernoffCatharine A Winstanley
Apr 10, 2021·Psychopharmacology·Xiaolin MeiXinwang Li
Oct 7, 2020·Pharmacology, Biochemistry, and Behavior·Britta HahnEdna F R Pereira

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