PMID: 8955507Nov 1, 1996Paper

Modulation of NK cell lytic function by endometrial secretory factors: potential role in endometriosis

American Journal of Reproductive Immunology : AJRI
E SomiglianaM Vignali

Abstract

Development and progression of endometriosis have been suggested to be related to a defect of NK cells in the ability to eliminate endometrial fragments regurgitated with menstrual debris in ectopic sites. However, it has not been clarified yet whether the origin of this defect has to be attributed to an intrinsic alteration of NK cell population or to a consequence of the environmental system. The present study was designed to evaluate whether soluble factors of endometrial origin might directly interfere with NK cell lytic function. Media conditioned by 20 endometrial stromal cultures (10 from endometriosis patients and 10 from women without the disease) were examined to test their effects on NK cell-mediated cytotoxicity directed against endometrial stromal targets. NK cells were purified from peripheral blood samples by a two steps panning technique and incubated overnight with and without endometrial supernatants. Thereafter, the percentage of lysis against endometrial cells was detected in a 51Cr cytotoxicity assay. Media conditioned by the overall endometrial stromal cultures exerted a significant suppressive effect (P < 0.001) on NK cell function when compared to control NK fractions (mean percentage of cytotoxicity +/-...Continue Reading

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Citations

Apr 20, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D VinatierP Dufour
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Aug 8, 2015·BioMed Research International·Soo Hyun AhnChandrakant Tayade
Jun 25, 2015·American Journal of Reproductive Immunology : AJRI·Uma ThiruchelvamCliona O'Farrelly
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Jun 14, 2016·BioMed Research International·InCheul JeungMee-Ran Kim
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Oct 4, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Hui-Li YangMing-Qing Li
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Sep 22, 2019·Journal of Clinical Medicine·Aneta ŚcieżyńskaJacek Malejczyk
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Apr 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Haiyuan Liu, Jing He Lang
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May 20, 2021·Minerva Obstetrics and Gynecology·Roberta VillanacciPaola Viganò

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