Modulation of NMDA receptor current in layer V pyramidal neurons of the rat prefrontal cortex by P2Y receptor activation

Cerebral Cortex
Kerstin WirknerPeter Illes

Abstract

Current responses to N-methyl-D-aspartate (NMDA) in layer V pyramidal neurons of the rat prefrontal cortex were potentiated by the P2 receptor agonists adenosine 5'-triphosphate (ATP) and uridine 5'-triphosphate (UTP). The failure of these nucleotides to induce inward current on fast local superfusion suggested the activation of P2Y rather than P2X receptors. The potentiation by ATP persisted in a Ca(2+)-free superfusion medium but was abolished by 1,2-bis(2-amino-5-fluorophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl) ester, cyclopiazonic acid, 7-nitroindazole, fluoroacetic acid, bafilomycin, and tetanus toxin, indicating that an astrocytic signaling molecule may participate. Because the metabotropic glutamate receptor (mGluR) agonists (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD) (group I/II) and (RS)-3,5-dihydroxyphenylglycine (group I) both imitated the effect of ATP and the group I mGluR antagonist 1-aminoindan-1,5-dicarboxylic acid or a combination of selective mGluR(1) (7-(hydroxyimino)-cyclopropa[b]chromen-1a-carboxylate) and mGluR(5) (2-methyl-6-(phenylethynyl)pyridine) antagonists abolished the facilitation by ATP, it was concluded that the signaling molecule may be glutamate. Pharmacologi...Continue Reading

Citations

Aug 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Claire MeissirelPeter Carmeliet
May 17, 2007·The Journal of General Physiology·David N Bowser, Baljit S Khakh
Jun 4, 2008·Biochemical and Biophysical Research Communications·Ruoyu ZhangHiroshi Nakanishi
Feb 15, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Laszlo KölesPeter Illes
May 29, 2008·Journal of Neural Transmission·Mitchell K P LaiPaul T Francis
Mar 14, 2009·Molecular Neurobiology·Alexei VerkhratskyGeoffrey Burnstock
Aug 6, 2009·The Journal of Comparative Neurology·Wolfgang FischerPeter Illes
Apr 7, 2007·The Journal of Physiology·C Justin LeeStephen F Traynelis
Jul 24, 2010·British Journal of Pharmacology·W NörenbergP Illes
Apr 28, 2011·Fundamental & Clinical Pharmacology·Linan ZhangYongli Wang
Oct 20, 2011·Glia·Lasse OrmelVidar Gundersen
Jul 18, 2017·The Journal of Clinical Investigation·Enmanuel J PerezDaniel J Liebl

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