PMID: 19926936Nov 21, 2009Paper

Modulation of noradrenergic neurotransmission in isolated rat radial artery

Journal of Pharmacological Sciences
Ana Cristina MartínezSara Benedito

Abstract

The present study was designed to characterize the neurogenic contraction of rat radial artery. Electrical field stimulation (EFS) evoked frequency-dependent contraction that was abolished by tetrodotoxin (neuronal Na(+) channel blocker), guanethidine (sympathetic neuron blocker), or phentolamine (alpha-adrenoceptor blocker). The alpha(1)-adrenoceptor antagonist prazosin inhibited endothelium-independent contractions to EFS, noradrenaline (NA), and the alpha(1)-adrenoceptor agonist phenylephrine. Rauwolscine, an alpha(2)-adrenoceptor antagonist, augmented nerve-mediated contractions and reduced sensitivity to NA and the alpha(2)-adrenoceptor agonist BHT-920. The beta-adrenoceptor antagonist propranolol diminished EFS-elicited contractions, while sensitivity to NA was enhanced by propranolol. Relaxations evoked by isoproterenol, a beta-adrenoceptor agonist, were abolished by propranolol. N(G)-Nitro-L-arginine (L-NOARG), a nitric oxide (NO) synthase inhibitor, increased both nerve-mediated and NA-induced responses in endothelium-intact, but not in endothelium-denuded arteries. Moreover, endothelium-dependent responses to BHT-920 and isoproterenol were modified by L-NOARG. Tetraethylammonium (TEA) or 4-aminopyridine, the Ca2+-acti...Continue Reading

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Citations

May 15, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Christos VosnakisDimitrios Panidis
Jan 9, 2013·Phytotherapy Research : PTR·Dragana ProtićLjiljana Gojković-Bukarica
Jun 8, 2012·Journal of Pharmacological Sciences·Maria Augusta Vieira-Coelho, Eduardo Moura
Feb 25, 2011·Journal of Cardiovascular Pharmacology·Ljiljana C Gojkovic-BukaricaHelmut Heinle
Oct 7, 2017·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·William F Jackson
Jun 3, 2021·International Journal of Molecular Sciences·Anastasia A ShvetsovaRudolf Schubert

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