Modulation of Obesity and Insulin Resistance by the Redox Enzyme and Adaptor Protein p66Shc

International Journal of Molecular Sciences
Stefano Ciciliot, Gian Paolo Fadini

Abstract

Initially reported as a longevity-related protein, the 66 kDa isoform of the mammalian Shc1 locus has been implicated in several metabolic pathways, being able to act both as an adaptor protein and as a redox enzyme capable of generating reactive oxygen species (ROS) when it localizes to the mitochondrion. Ablation of p66Shc has been shown to be protective against obesity and the insurgence of insulin resistance, but not all the studies available in the literature agree on these points. This review will focus in particular on the role of p66Shc in the modulation of glucose homeostasis, obesity, body temperature, and respiration/energy expenditure. In view of the obesity and diabetes epidemic, p66Shc may represent a promising therapeutic target with enormous implications for human health.

References

Nov 23, 2000·Current Opinion in Genetics & Development·L LuziP G Pelicci
Jan 26, 2002·British Medical Bulletin·C N Hales, D J Barker
Dec 17, 2002·Nature·Martin HolzenbergerYves Le Bouc
Jan 30, 2004·Molecular and Cellular Biology·Sonia PaciniCosima T Baldari
Jul 5, 2005·Mechanisms of Ageing and Development·S PandolfiC Franceschi
Feb 17, 2006·The Journal of Biological Chemistry·Shino NemotoToren Finkel
Mar 8, 2006·The Journal of Cell Biology·Firdous A KhandayKaikobad Irani
Nov 4, 2006·Biological Chemistry·Francesca OrsiniEnrica Migliaccio
Dec 29, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Francesco CosentinoMassimo Volpe
Oct 8, 2008·The Journal of Biological Chemistry·Ina BerniakovichMarco Giorgio
Oct 30, 2008·American Journal of Physiology. Endocrinology and Metabolism·Annalisa NatalicchioFrancesco Giorgino
Jul 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sofia Chiatamone RanieriGiovambattista Pani
Nov 3, 2010·Aging Cell·Alexey A TomilovGino A Cortopassi
Apr 22, 2011·Archives of Physiology and Biochemistry·Annalisa NatalicchioFrancesco Giorgino
Nov 16, 2011·Aging Cell·Marco GiorgioPier G Pelicci
May 17, 2012·Mechanisms of Ageing and Development·Jennifer H SternJon J Ramsey
Feb 5, 2013·Vitamins and Hormones·Sofia Chiatamone RanieriGiovambattista Pani
Apr 23, 2013·Oxidative Medicine and Cellular Longevity·Elena De MarchiPaolo Pinton
Jul 16, 2013·Methods in Enzymology·Mirella TrineiMarco Giorgio
Dec 18, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jon J RamseyRoger B McDonald
Feb 20, 2014·Science Signaling·Mohamed A SolimanTony Pawson
May 9, 2014·Molecular Biology of the Cell·Masaki Miyazawa, Yoshiaki Tsuji
Jun 15, 2015·Biochemistry. Biokhimii︠a︡·A Y AndreyevA A Starkov

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Citations

Aug 19, 2020·Antioxidants & Redox Signaling·Stefano MasiSarah Costantino
Jun 6, 2019·Basic Research in Cardiology·Kerstin BoenglerRainer Schulz
Aug 17, 2020·Ageing Research Reviews·Hilal Ahmad MirFirdous A Khanday
Jul 29, 2021·Advanced Science·Sevgican DemirBilgen Ekim Üstünel

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Methods Mentioned

BETA
nucleotide exchange
environmental stress
lipidation
environmental stresses

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