Modulation of ornithine decarboxylase gene transcript levels by differentiation inducers in human promyelocytic leukemia HL60 cells.

Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists
C Rius, P Aller

Abstract

We have analyzed the changes in the steady-state levels of ornithine decarboxylase (ODC) mRNA during differentiation of HL60 cells, a human promyelocytic leukemia cell line. Induction of differentiation with either retinoic acid, dimethylsulfoxide, dibutyryl cAMP or dihydroxy-vitamin D3 resulted in a decrease of the cellular content of ODC RNA. Such a decrease occurred late after induction and coincided with the slowing of cell growth activity and with the expression of a cell surface differentiation marker (CD11b antigen). In contrast, the inducers provoked a rapid reduction of c-myc RNA levels, which preceded both the slowing of cell growth and the expression of the differentiation marker. When the cells were treated with a phorbol ester (TPA), the down-regulation of ODC was preceded by a transient increase in the steady-state levels of this RNA. However, such an increase was not observed with other inducers. The possible significance of these results in relation to the control of HL60 cell differentiation is discussed.

References

Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·G Ketner, T J Kelly
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G RoveraC Damsky
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K Yokoyama, F Imamoto
Aug 1, 1989·European Journal of Immunology·C CabañasC Bernabeu
Feb 15, 1987·The Biochemical Journal·L Alhonen-HongistoJ Jänne
Mar 1, 1986·The Biochemical Journal·A E Pegg
Apr 14, 1987·Biochemical and Biophysical Research Communications·L Alhonen-HongistoJ Jänne
Sep 1, 1987·Journal of Cellular Physiology·L KaczmarekJ K de Riel
Nov 1, 1986·Molecular and Cellular Biology·S FerrariR Baserga
Jan 1, 1986·Annual Review of Cell Biology·U Kikkawa, Y Nishizuka
Jul 1, 1987·Molecular and Cellular Biology·A Katz, C Kahana
Feb 15, 1985·Biochemical and Biophysical Research Communications·T WatanabeD Kufe
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P S Thomas
Jan 1, 1984·Annual Review of Biochemistry·C W Tabor, H Tabor
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R R HirschhornR Baserga
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R Dalla-FaveraF Wong-Staal
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K K KontulaO A Jänne
Sep 16, 1981·Biochemical and Biophysical Research Communications·D R Bethell, A E Pegg
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E HubermanT Slaga

❮ Previous
Next ❯

Citations

Nov 1, 1992·Journal of Cellular Biochemistry·A F Ferrier, R R Hirschhorn
Feb 24, 2015·European Journal of Medicinal Chemistry·Ashish Radadiya, Anamik Shah
Sep 1, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Xuening WangGeorge P Studzinski
Apr 4, 2009·Ground Water·David K Kreamer, Brent Usher
Aug 1, 1994·European Journal of Haematology·N Takahashi, T R Breitman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.